ArticleChemical communications (Cambridge, England)2017
6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis.
Article in Chemical communications (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Isothiourea-Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6- and 1,4-Additions.ChemistryEurope · 2023Article
- Recent Advances in the Synthesis of 3,4-Dihydropyran-2-Ones Organocatalyzed byMolecules (Basel, Switzerland) · 2023Review
- Cooperative Palladium/Isothiourea Catalyzed Enantioselective Formal (3+2) Cycloaddition of Vinylcyclopropanes and α,β-Unsaturated Esters.Angewandte Chemie (International ed. in English) · 2022Article
- Catalytic enantioselective synthesis of 1,4-dihydropyridinesChemical science · 2021Article
- Generation and Reactivity of C(1)-Ammonium Enolates by Using Isothiourea Catalysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Tandem sequential catalytic enantioselective synthesis of highly-functionalised tetrahydroindolizine derivatives.Chemical science · 2020Article
- Tautomerism as primary signaling mechanism in metal sensing: the case of amide group.Beilstein journal of organic chemistry · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diastereo- and enantioselectivity.
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Registered trials
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