Evidence map›Paper›PMID 28133536›Full record

ArticleJournal of materials chemistry. B2016

Approaches for building bioactive elements into synthetic scaffolds for bone tissue engineering.

Venu Kesireddy, F Kurtis Kasper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration.Materials science & engineering. C, Materials for biological applications · 2020
    Review
  18. Article
  19. Review
  20. [Recent research progress of bioactivity mechanism and application of bone repair materials].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Venu KesireddyDepartment of Orthodontics, The University of Texas Health Science Center at Houston, School of Dentistry.
F Kurtis KasperDepartment of Orthodontics, The University of Texas Health Science Center at Houston, School of Dentistry.

Funding

Three-dimensional Model of Human Ewing SarcomaR01CA180279 · NCI · RICE UNIVERSITY · PI KASPER, FRED KURTIS, LUDWIG, JOSEPH A · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA180279
6 · The paper itself

Abstract

Bone tissue engineering (BTE) is emerging as a possible solution for regeneration of bone in a number of applications. For effective utilization, BTE scaffolds often need modifications to impart biological cues that drive diverse cellular functions such as adhesion, migration, survival, proliferation, differentiation, and biomineralization. This review provides an outline of various approaches for building bioactive elements into synthetic scaffolds for BTE and classifies them broadly under two distinct schemes; namely, the top-down approach and the bottom-up approach. Synthetic and natural routes for top-down approaches to production of bioactive constructs for BTE, such as generation of scaffold-extracellular matrix (ECM) hybrid constructs or decellularized and demineralized scaffolds, are provided. Similarly, traditional scaffold-based bottom-up approaches, including growth factor immobilization or peptide-tethered scaffolds, are provided. Finally, a brief overview of emerging bottom-up approaches for generating biologically active constructs for BTE is given. A discussion of the key areas for further investigation, challenges, and opportunities is also presented.

Indexed as

biological modificationbiomimetic scaffoldsbone tissue engineeringextracellular matrixsynthetic scaffolds

Identifiers

PMID28133536
PMCPMC5267491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.