Evidence map›Paper›PMID 28133533›Full record

ArticleChemical science2015

Small molecule antagonists of cell-surface heparan sulfate and heparin-protein interactions.

Ryan J Weiss, Philip L S M Gordts, Dzung Le, Ding Xu, Jeffrey D Esko, Yitzhak Tor

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Dynamic Combinatorial Optimization ofJournal of medicinal chemistry · 2022
    Article
  8. Article
  9. Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function.Frontiers in cell and developmental biology · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Targeting heparin and heparan sulfate protein interactions.Organic & biomolecular chemistry · 2017
    Review
  16. Crystal structure of trans-N,N'-bis-(3,5-di-tert-butyl-2-hy-droxy-phen-yl)oxamide methanol monosolvate.Acta crystallographica. Section E, Crystallographic communications · 2016
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ryan J WeissDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093-0358, USA.
Philip L S M GordtsCellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093-0687, USA.
Dzung LeDepartment of Medicine, University of California, San Diego, La Jolla, CA, 92093-0612, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, 92093-0687, USA.
Ding XuDepartment of Oral Biology, University at Buffalo, Buffalo, NY, 14260-1660, USA.
Jeffrey D EskoCellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093-0687, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, 92093-0687, USA.
Yitzhak TorDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093-0358, USA; Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, 92093-0687, USA.
University of California System · USUniversity of California, San Diego · USUniversity at Buffalo, State University of New York · US

Funding

Siglec Modulation of Inflammatory ResponsesP01HL107150 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LE, DZUNG T · 2011 to 2017
$18.0M
Cellular uptake of glycoside-based transportersR01GM077471 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOR, YITZHAK · 2007 to 2010
$1.1M
NHLBI NIH HHS P01 HL107150NIGMS NIH HHS R01 GM077471
6 · The paper itself

Abstract

Surfen, bis-2-methyl-4-amino-quinolyl-6-carbamide, was previously reported as a small molecule antagonist of heparan sulfate (HS), a key cell-surface glycosaminoglycan found on all mammalian cells. To generate structure-activity relationships, a series of rationally designed surfen analogs was synthesized, where its dimeric structure, exocyclic amines, and urea linker region were modified to probe the role of each moiety in recognizing HS. An

Identifiers

PMID28133533
PMCPMC5267326
OpenAlexW2104187141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.