ArticleToxicological research2017
Recognition of Transmembrane Protein 39A as a Tumor-Specific Marker in Brain Tumor.
Article in Toxicological research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- TMEM39A acts as a novel profibrotic factor to activate hepatic stellate cells partially via the cell adhesion molecule signaling axis.Frontiers in cell and developmental biology · 2026Article
- TME-Related Biomimetic Strategies Against Cancer.International journal of nanomedicine · 2024Review
- The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts.Journal of ginseng research · 2022Article
- The conserved autoimmune-disease risk geneProceedings of the National Academy of Sciences of the United States of America · 2021Article
- The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response.PLoS genetics · 2021Article
- Beneficial effects ofToxicological research · 2021Article
- Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death.Toxicological research · 2020Article
- 1,2-Dichloropropane (1,2-DCP)-Induced Angiogenesis in Dermatitis.Toxicological research · 2019Article
- A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts.Journal of ginseng research · 2019Article
- Transmembrane Protein 39A Promotes the Replication of Encephalomyocarditis VirusFrontiers in microbiology · 2019Article
- Preliminary Study on the Role of TMEM39A Gene in Multiple Sclerosis.Journal of molecular neuroscience : MN · 2017Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. However, any possible involvement of TMEM39A in cancer remains largely unknown. In the present report, we provide evidence that TMEM39A may play a role in brain tumors. Western blotting using an anti-TMEM39A antibody indicated that TMEM39A was overexpressed in glioblastoma cell lines, including U87-MG and U251-MG. Deep-sequencing transcriptomic profiling of U87-MG and U251-MG cells revealed that TMEM39A transcripts were upregulated in such cells compared with those of the cerebral cortex. Confocal microscopic analysis of U251-MG cells stained with anti-TMEM39A antibody showed that TMEM39A was located in dot-like structures lying close to the nucleus. TMEM39A probably located to mitochondria or to endosomes. Immunohistochemical analysis of glioma tissue specimens indicated that TMEM39A was markedly upregulated in such samples. Bioinformatic analysis of the Rembrandt knowledge base also supported upregulation of TMEM39A mRNA levels in glioma patients. Together, the results afford strong evidence that TMEM39A is upregulated in glioma cell lines and glioma tissue specimens. Therefore, TMEM39A may serve as a novel diagnostic marker of, and a therapeutic target for, gliomas and other cancers.
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