ArticleFrontiers in neurology2016
Pattern of Reduced Functional Connectivity and Structural Abnormalities in Parkinson's Disease: An Exploratory Study.
Article in Frontiers in neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Integrated PET/MRI for the evaluation of gray matter atrophy and metabolic changes in idiopathic Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Connectivity and function are coupled across cognitive domains throughout the brain.Network neuroscience (Cambridge, Mass.) · 2026Article
- Sparse Deep Neural Network for Encoding and Decoding the Structural Connectome.IEEE journal of translational engineering in health and medicine · 2024Article
- Surface-based morphological patterns associated with neuropsychological performance, symptom severity, and treatment response in Parkinson's disease.Annals of translational medicine · 2022Article
- Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease.NeuroImage. Clinical · 2022Article
- Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains.Brain communications · 2022Article
- Machine Learning Models for Diagnosis of Parkinson's Disease Using Multiple Structural Magnetic Resonance Imaging Features.Frontiers in aging neuroscience · 2022Article
- Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson's disease.Journal of neurology · 2021Article
- ALFF and ReHo Mapping Reveals Different Functional Patterns in Early- and Late-Onset Parkinson's Disease.Frontiers in neuroscience · 2020Article
- Resting-State Cerebello-Cortical Dysfunction in Parkinson's Disease.Frontiers in neurology · 2020Article
- Emergent Functional Network Effects in Parkinson Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.Frontiers in neurology · 2019Article
- Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.Translational neurodegeneration · 2019Review
- Assessment of a prognostic MRI biomarker in early de novo Parkinson's disease.NeuroImage. Clinical · 2019Article
- Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder.Neurology · 2018Article
- Is Diffusion Tensor Imaging a Good Biomarker for Early Parkinson's Disease?Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMRI brain changes in Parkinson's disease (PD) are controversial.
objectivesWe aimed to describe structural and functional changes in PD.
methodsSixty-six patients with PD (57.94 ± 10.25 years) diagnosed according to the UK Brain Bank criteria were included. We performed a whole brain analysis using voxel-based morphometry (VBM-SPM 8 software), cortical thickness (CT) using CIVET, and resting-state fMRI using the Neuroimaging Analysis Kit software to compare patients and controls. For VBM and CT we classified subjects into three groups according to disease severity: mild PD [Hoehn and Yahr scale (HY) 1-1.5], moderate PD (HY 2-2.5), and severe PD (HY 3-5).
resultsWe observed gray matter atrophy in the insula and inferior frontal gyrus in the moderate PD and in the insula, frontal gyrus, putamen, cingulated, and paracingulate gyri in the severe groups. In the CT analysis, in mild PD, cortical thinning was restricted to the superior temporal gyrus, gyrus rectus, and olfactory cortex; in the moderate group, the postcentral gyrus, supplementary motor area, and inferior frontal gyrus were also affected; in the severe PD, areas such as the precentral and postentral gyrus, temporal pole, fusiform, and occipital gyrus had reduced cortical thinning. We observed altered connectivity at the default mode, visual, sensorimotor, and cerebellar networks.
conclusionSubjects with mild symptoms already have cortical involvement; however, further cerebral involvement seems to follow Braak's proposed mechanism. Similar regions are affected both structurally and functionally. We believe the combination of different MRI techniques may be useful in evaluating progressive brain involvement and they may eventually be used as surrogate markers of disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.