Evidence map›Paper›PMID 28133433›Full record

ArticleNew journal of chemistry = Nouveau journal de chimie2016

Bioconjugatable, PEGylated Hydroporphyrins for Photochemistry and Photomedicine. Narrow-Band, Near-Infrared-Emitting Bacteriochlorins.

Nuonuo Zhang, Jianbing Jiang, Mengran Liu, Masahiko Taniguchi, Amit Kumar Mandal, Rosemary B Evans-Storms, J Bruce Pitner, David F Bocian, Dewey Holten, Jonathan S Lindsey

Open access · greenAbstract read
In one paragraph

Article in New journal of chemistry = Nouveau journal de chimie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nuonuo ZhangDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204.
Jianbing JiangDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204.
Mengran LiuDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204.
Masahiko TaniguchiDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204.
Amit Kumar MandalDepartment of Chemistry, Washington University, St. Louis, MO 63130-4889.
Rosemary B Evans-StormsNIRvana Sciences, Research Triangle Park, NC 27709-3169.
J Bruce PitnerNIRvana Sciences, Research Triangle Park, NC 27709-3169.
David F BocianDepartment of Chemistry, University of California, Riverside, CA 92521-0403.
Dewey HoltenDepartment of Chemistry, Washington University, St. Louis, MO 63130-4889.
Jonathan S LindseyDepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204.
North Carolina State University · USTriangle · USWashington University in St. Louis · USUniversity of California, Riverside · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
New Class of Bright, Sharp, Tunable Near-Infrared Fluorophores for Flow CytoR41AI112302 · NIAID · NIRVANA SCIENCES, INC. · PI PITNER, JAMES BRUCE · 2014 to 2014
$225k
NCI NIH HHS P30 CA016086NIAID NIH HHS R41 AI112302
6 · The paper itself

Abstract

Synthetic bacteriochlorins absorb in the near-infrared (NIR) region and are versatile analogues of natural bacteriochlorophylls. The utilization of these chromophores in energy sciences and photomedicine requires the ability to tailor their physicochemical properties, including the incorporation of units to impart water solubility. Herein, we report the synthesis, from two common bacteriochlorin building blocks, of five wavelength-tunable, bioconjugatable and water-soluble bacteriochlorins along with two non-bioconjugatable benchmarks. Each bacteriochlorin bears short polyethylene glycol (PEG) units as the water-solubilizing motif. The PEG groups are located at the 3,5-positions of aryl groups at the pyrrolic β-positions to suppress aggregation in aqueous media. A handle containing a single carboxylic acid is incorporated to allow bioconjugation. The seven water-soluble bacteriochlorins in water display Q

Identifiers

PMID28133433
PMCPMC5268740
OpenAlexW2500113903

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.