Evidence map›Paper›PMID 28132901›Full record

ArticleBiochimica et biophysica acta. Biomembranes2017

Modulation of lipid membrane structural and mechanical properties by a peptidomimetic derived from reduced amide scaffold.

Nawal K Khadka, Peng Teng, Jianfeng Cai, Jianjun Pan

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  3. Interaction of βInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nawal K KhadkaDepartment of Physics, University of South Florida, Tampa, FL 33620, United States.
Peng TengDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Jianfeng CaiDepartment of Chemistry, University of South Florida, Tampa, FL 33620, United States.
Jianjun PanDepartment of Physics, University of South Florida, Tampa, FL 33620, United States. Electronic address: panj@usf.edu.
University of South Florida · US

Funding

Requesting HPLC for the project of "Alpha-AApeptides as a Novel Class of Antimicrobial Biomaterials"R01GM112652 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG · 2015 to 2019
$1.5M
Characterizing Interactions between Bacterial Membranes and Peptidomimetics for the Development of Antibiotics Targeting Multidrug Resistant BacteriaR15GM117531 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI PAN, JIANJUN · 2016 to 2016
$362k
NIGMS NIH HHS R01 GM112652NIGMS NIH HHS R15 GM117531
6 · The paper itself

Abstract

Understanding how antimicrobial peptidomimetics interact with lipid membranes is important in battling multidrug resistant bacterial pathogens. We study the effects of a recently reported peptidomimetic on lipid bilayer structural and mechanical properties. The compound referred to as E107-3 is synthesized based on the acylated reduced amide scaffold and has been shown to exhibit good antimicrobial potency. Our vesicle leakage assay indicates that the compound increases lipid bilayer permeability. We use micropipette aspiration to explore the kinetic response of giant unilamellar vesicles (GUVs). Exposure to the compound causes the GUV protrusion length L

Indexed as

AmidesCalciumFluoresceinsLipid BilayersMicroscopy, Atomic ForcePeptidomimeticsUnilamellar LiposomesAmidesCalciumFluoresceinsfluorexonLipid BilayersPeptidomimeticsUnilamellar LiposomesArea compressibility modulusAtomic force microscopyForce spectroscopyPlanar lipid bilayerPuncture force

Identifiers

PMID28132901
PMCPMC5365377
OpenAlexW2581988864

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.