Trial reportJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2017
Use of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis.
Trial report in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05392855 (Symptom Based Performance of Airway Clearance Therapy After Starting Highly Effective CFTR Modulator Therapy for Cystic Fibrosis), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Symptom Based Performance of Airway Clearance Therapy After Starting Highly Effective CFTR Modulator Therapy for Cystic Fibrosis
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis.The Cochrane database of systematic reviews · 2019Pooled it
- Trial
- Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025Review
- Mapping Regional Changes in Multiple-Timepoint Hyperpolarized Gas Ventilation Images and Validation by Radiologist Score.International journal of biomedical imaging · 2025Article
- Contrast agent-free functional magnetic resonance imaging with matrix pencil decomposition to quantify abnormalities in lung perfusion and ventilation in patients with cystic fibrosis.Frontiers in medicine · 2024Article
- The impact of SARS-CoV-2 infection in patients with cystic fibrosis undergoing CFTR channel modulators treatment: a literature review.Respiratory research · 2023Review
- [Magnetic resonance imaging of the lung : State of the art].Radiologie (Heidelberg, Germany) · 2023Article
- Lung functional imaging.Breathe (Sheffield, England) · 2023Article
- Early Effects of Elexacaftor-Tezacaftor-Ivacaftor Therapy on Magnetic Resonance Imaging in Patients with Cystic Fibrosis and Advanced Lung Disease.Journal of clinical medicine · 2022Article
- Lung MRI with hyperpolarised gases: current & future clinical perspectives.The British journal of radiology · 2022Review
- Quantification of pulmonary perfusion abnormalities using DCE-MRI in COPD: comparison with quantitative CT and pulmonary function.European radiology · 2022Article
- Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.Respirology (Carlton, Vic.) · 2022Review
- Xenon ventilation MRI in difficult asthma: initial experience in a clinical setting.ERJ open research · 2021Article
- In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021Review
- Novel imaging techniques for cystic fibrosis lung disease.Pediatric pulmonology · 2021Review
- Commentary: Expert Opinion to "Imaging Bronchopulmonary Dysplasia-A Multimodality Update".Frontiers in medicine · 2021Article
- Novel Thoracic MRI Approaches for the Assessment of Pulmonary Physiology and Inflammation.Advances in experimental medicine and biology · 2021Article
- Current state of the art MRI for the longitudinal assessment of cystic fibrosis.Journal of magnetic resonance imaging : JMRI · 2020Review
- Airway Inflammation and Host Responses in the Era of CFTR Modulators.International journal of molecular sciences · 2020Review
- Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients.Pediatric radiology · 2020Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis pilot study evaluated the effect of short- and long-term ivacaftor treatment on hyperpolarized
methodsPart A (single-blind) comprised 4weeks of ivacaftor treatment; Part B (open-label) comprised 48weeks of treatment. The primary outcome was change from baseline in total ventilation defect (TVD; total defect volume:total lung volume ratio).
resultsMean change in TVD ranged from -8.2% (p=0.0547) to -12.8% (p=0.0078) in Part A (n=8) and -6.3% (p=0.1953) to -9.0% (p=0.0547) in Part B (n=8) as assessed by human reader and computer algorithm, respectively.
conclusionsTVD responded to ivacaftor therapy.
Indexed as
Identifiers
28132845What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.