ArticleNeuron2017
Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The Drosophila escape motor circuit shows differential vulnerability to aging linked to functional decay.PLoS biology · 2025Article
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- Neural cell competition sculpting brain from cradle to grave.National science review · 2025Review
- Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.Neuron · 2024Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.bioRxiv : the preprint server for biology · 2023Article
- Article
- Neuronal excitability as a regulator of circuit remodeling.Current biology : CB · 2023Article
- Article
- Food supplementation with wheat gluten leads to climbing performance decline inmicroPublication biology · 2022Article
- Constructing and Tuning Excitatory Cholinergic Synapses: The Multifaceted Functions of Nicotinic Acetylcholine Receptors inFrontiers in cellular neuroscience · 2021Review
- Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction.eLife · 2020Article
- Different functions of two putative Drosophila αScientific reports · 2020Article
- Activity Dependent and Independent Determinants of Synaptic Size Diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors.Developmental cell · 2019Article
- Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjustProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output duringThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Neural Circuits: Reduced Inhibition in Fragile X Syndrome.Current biology : CB · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Brain development requires correct targeting of multiple thousand synaptic terminals onto staggeringly complex dendritic arbors. The mechanisms by which input synapse numbers are matched to dendrite size, and by which synaptic inputs from different transmitter systems are correctly partitioned onto a postsynaptic arbor, are incompletely understood. By combining quantitative neuroanatomy with targeted genetic manipulation of synaptic input to an identified Drosophila neuron, we show that synaptic inputs of two different transmitter classes locally direct dendrite growth in a competitive manner. During development, the relative amounts of GABAergic and cholinergic synaptic drive shift dendrites between different input domains of one postsynaptic neuron without affecting total arbor size. Therefore, synaptic input locally directs dendrite growth, but intra-neuronal dendrite redistributions limit morphological variability, a phenomenon also described for cortical neurons. Mechanistically, this requires local dendritic Ca
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