Evidence map›Paper›PMID 28132831›Full record

ArticleNeuron2017

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.

Amit Agarwal, Pei-Hsun Wu, Ethan G Hughes, Masahiro Fukaya, Max A Tischfield, Abraham J Langseth, Denis Wirtz, Dwight E Bergles

Abstract readVideo-Audio Media
In one paragraph

Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 264 papers.

0numbers the graph read from it
0cells of the map it votes in
264citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

264 citing papers in PubMed.

  1. Article
  2. Context-Dependent modulation of astrocytic CaJournal of computational neuroscience · 2026
    Article
  3. Review
  4. Cocaine facilitates CaMolecular psychiatry · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Multi-timescale Computation by Astrocytes.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Mitochondrial CaBiomolecules · 2026
    Review
  18. Article
  19. Review
  20. Review

204 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Amit AgarwalThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Pei-Hsun WuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ethan G HughesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Masahiro FukayaDepartment of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
Max A TischfieldDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Abraham J LangsethThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Denis WirtzDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dwight E BerglesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: dbergles@jhmi.edu.

Funding

Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
Semaphorin Signaling and Plasticity at the Excitatory SynapseP50MH100024 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2013 to 2017
$9.5M
Signaling to and from the SynapseP50MH084020 · NIMH · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 2008 to 2012
$9.2M
NIMH NIH HHS P50 MH084020NIMH NIH HHS P50 MH100024NINDS NIH HHS P30 NS050274
6 · The paper itself

Abstract

Astrocytes extend highly branched processes that form functionally isolated microdomains, facilitating local homeostasis by redistributing ions, removing neurotransmitters, and releasing factors to influence blood flow and neuronal activity. Microdomains exhibit spontaneous increases in calcium (Ca

Indexed as

Amyotrophic Lateral SclerosisAnimalsAstrocytesCalciumEndoplasmic ReticulumInositol 1,4,5-TrisphosphateMiceMitochondriaMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreOxidative PhosphorylationReactive Oxygen SpeciesSuperoxide Dismutase-1CalciumInositol 1,4,5-TrisphosphateMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreReactive Oxygen SpeciesSuperoxide Dismutase-1astrocyteATPcalciumcortexin vivometabolismmicrodomainmitochondriatwo-photon

Identifiers

PMID28132831
PMCPMC5308886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.