ArticleNeuron2017
Studying Brain Circuit Function with Dynamic Causal Modeling for Optogenetic fMRI.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022Pooled it
- Simultaneous single-cell calcium imaging of neuronal population activity and brain-wide BOLD fMRI.Nature methods · 2026Article
- Structurally informed resting-state effective connectivity recapitulates cortical hierarchy.bioRxiv : the preprint server for biology · 2025Article
- Spectral imprint of structural embedding in effective connectivity.bioRxiv : the preprint server for biology · 2025Article
- Advanced preclinical functional magnetic resonance imaging of the brain.Npj imaging · 2025Review
- Mapping effective connectivity by virtually perturbing a surrogate brain.Nature methods · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Structurally informed models of directed brain connectivity.Nature reviews. Neuroscience · 2025Review
- Peripheral contributions to resting state brain dynamics.Nature communications · 2024Article
- Motor network dynamic resting state fMRI connectivity of neurotypical children in regions affected by cerebral palsy.Frontiers in human neuroscience · 2024Article
- Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation.Nature communications · 2023Article
- The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit.Psychoradiology · 2023Article
- Development of a synchronous recording and photo-stimulating electrode in multiple brain neurons.Frontiers in neuroscience · 2023Article
- Deriving causal relationships in resting-state functional connectivity using SSFO-based optogenetic fMRI.Journal of neural engineering · 2022Article
- Solving brain circuit function and dysfunction with computational modeling and optogenetic fMRI.Science (New York, N.Y.) · 2022Review
- Connecting the dots between cell populations, whole-brain activity, and behavior.Neurophotonics · 2022Article
- What Models and Tools can Contribute to a Better Understanding of Brain Activity?Frontiers in network physiology · 2022Article
- High-sensitivity detection of optogenetically-induced neural activity with functional ultrasound imaging.NeuroImage · 2021Article
- Brain-wide neural dynamics of poststroke recovery induced by optogenetic stimulation.Science advances · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Defining the large-scale behavior of brain circuits with cell type specificity is a major goal of neuroscience. However, neuronal circuit diagrams typically draw upon anatomical and electrophysiological measurements acquired in isolation. Consequently, a dynamic and cell-type-specific connectivity map has never been constructed from simultaneous measurements across the brain. Here, we introduce dynamic causal modeling (DCM) for optogenetic fMRI experiments-which uniquely allow cell-type-specific, brain-wide functional measurements-to parameterize the causal relationships among regions of a distributed brain network with cell type specificity. Strikingly, when applied to the brain-wide basal ganglia-thalamocortical network, DCM accurately reproduced the empirically observed time series, and the strongest connections were key connections of optogenetically stimulated pathways. We predict that quantitative and cell-type-specific descriptions of dynamic connectivity, as illustrated here, will empower novel systems-level understanding of neuronal circuit dynamics and facilitate the design of more effective neuromodulation therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.