Evidence map›Paper›PMID 28132812›Full record

ArticleCurrent biology : CB2017

Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites.

Adam Mani, Gregory W Schwartz

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Article
  3. Retinal ganglion cells encode the direction of motion outside their classical receptive field.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  19. The acute effect of atropine eye drops on the human full-field electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adam ManiDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Gregory W SchwartzDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208, USA. Electronic address: greg.schwartz@northwestern.edu.
Northwestern University · US

Funding

Novel circuit mapping strategies to reverse engineer the retinaDP2EY026770 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHWARTZ, GREGORY WILLIAM · 2015 to 2015
$2.3M
NEI NIH HHS DP2 EY026770
6 · The paper itself

Abstract

Center-surround antagonism has been used as the canonical model to describe receptive fields of retinal ganglion cells (RGCs) for decades. We describe a newly identified RGC type in the mouse, called the ON delayed (OND) RGC, with receptive field properties that deviate from center-surround organization. Responding with an unusually long latency to light stimulation, OND RGCs respond earlier as the visual stimulus increases in size. Furthermore, OND RGCs are excited by light falling far beyond their dendrites. We unravel details of the circuit mechanisms behind these phenomena, revealing new roles for inhibition in controlling both temporal and spatial receptive field properties. The non-canonical receptive field properties of the OND RGC-integration of long temporal and large spatial scales-suggest that unlike typical RGCs, it may encode a slowly varying, global property of the visual scene.

Indexed as

AnimalsDendritesFemaleMaleMiceMice, Inbred C57BLNeural InhibitionPhotic StimulationReaction TimeRetinal Ganglion Cellscenter-surroundcircuitextra-dendriticganglion cellsimage focuslatencymousereceptive fieldretinaserial inhibition

Identifiers

PMID28132812
PMCPMC5319888
OpenAlexW2582609980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.