Evidence map›Paper›PMID 28132477›Full record

ReviewPostepy biochemii2016

The young person's guide to the PDB.

Wladek Minor, Zbigniew Dauter, Mariusz Jaskolski

Open access · diamondAbstract readReview
In one paragraph

Review in Postepy biochemii, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Wladek MinorUniversity of Virginia, Charlottesville, VA 22908, USA.
Zbigniew DauterMacromolecular Crystallography Laboratory, National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439, USA.
Mariusz JaskolskiZakład Krystalografii, Wydział Chemii, Uniwersytet im. A. Mickiewicza w Poznaniu ul. Grunwaldzka 6, 60-780 Poznań, Polska.
Adam Mickiewicz University in Poznań · PLArgonne National Laboratory · USUniversity of Virginia · US

Funding

Midwest Center for Structural GenomicsU54GM094585 · NIGMS · UNIVERSITY OF CHICAGO · PI ORENGO, CHRISTINE · 2010 to 2014
$33.7M
Macromolecular Crystallography Research with Synchrotron RadiationZIABC010378 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DAUTER, ZBIGNIEW · 2009 to 2020
$18.8M
The Protein Structure Inittiative KnowledgebaseU01GM093324 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI BERMAN, HELEN M · 2010 to 2015
$12.9M
X-RAY CRYSTALLOGRAPHY OF MACROMOLECULESR01GM053163 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MINOR, WLADEK, OTWINOWSKI, ZBYSZEK · 1996 to 2014
$6.3M
Integrated resource for reproducibility in macromolecular crystallographyU01HG008424 · NHGRI · UNIVERSITY OF VIRGINIA · PI MINOR, WLADEK · 2015 to 2017
$1.5M
X-ray data analysis in the presence of structural variability - Administrative SupplementR01GM117080 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI MINOR, WLADEK, OTWINOWSKI, ZBYSZEK · 2015 to 2018
$1.4M
Metal binding sites in macromolecular structuresR01GM117325 · NIGMS · UNIVERSITY OF VIRGINIA · PI MINOR, WLADEK · 2016 to 2019
$1.3M
NHGRI NIH HHS U01 HG008424NIAID NIH HHS HHSN272201200026CNIGMS NIH HHS R01 GM053163NIGMS NIH HHS R01 GM117080NIGMS NIH HHS R01 GM117325NIGMS NIH HHS U01 GM093324NIGMS NIH HHS U54 GM094585
6 · The paper itself

Abstract

The Protein Data Bank (PDB), created in 1971 when merely seven protein crystal structures were known, today holds over 120, 000 experimentally-determined three-dimensional models of macromolecules, including gigantic structures comprised of hundreds of thousands of atoms, such as ribosomes and viruses. Most of the deposits come from X-ray crystallography experiments, with important contributions also made by NMR spectroscopy and, recently, by the fast growing Cryo-Electron Microscopy. Although the determination of a macromolecular crystal structure is now facilitated by advanced experimental tools and by sophisticated software, it is still a highly complicated research process requiring specialized training, skill, experience and a bit of luck. Understanding the plethora of structural information provided by the PDB requires that its users (consumers) have at least a rudimentary initiation. This is the purpose of this educational overview.

Indexed as

Databases, ProteinCrystallography, X-RayGuidelines as TopicMicroscopy, ElectronNuclear Magnetic Resonance, BiomolecularProtein ConformationProteinsProteinsdata miningmacromolecular structureProtein Data Bankstructural biologystructural databasesstructure validation

Identifiers

PMID28132477
PMCPMC5610703
OpenAlexW2970929303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.