Evidence map›Paper›PMID 28132162›Full record

Trial reportJournal of pharmacokinetics and pharmacodynamics2017

Population pharmacokinetics and pharmacodynamics of IONIS-GCGR

Kenneth T Luu, Erin S Morgan, Sanjay Bhanot, Richard Geary, Anne Smith, Claudette Bethune, Lynnetta Watts, Scott Henry, Yanfeng Wang

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of pharmacokinetics and pharmacodynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Antisense Oligonucleotide Therapeutics Targeting Age-Related Diseases.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kenneth T LuuClinical Pharmacology, Ionis Pharmaceuticals, Inc., 2855 Gazelle Ct., Carlsbad, CA, 92010, USA. kenneth.t.luu@gmail.com.ORCID 0000-0003-4839-5331
Erin S MorganClinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Sanjay BhanotClinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Richard GearyClinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Anne SmithClinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Claudette BethuneClinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Lynnetta WattsClinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Scott HenryNonclinical Development, Ionis Pharmaceuticals, Carlsbad, CA, USA.
Yanfeng WangClinical Pharmacology, Ionis Pharmaceuticals, Inc., 2855 Gazelle Ct., Carlsbad, CA, 92010, USA.
Ionis Pharmaceuticals (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IONIS-GCGR

Indexed as

AdolescentAdultAgedBlood GlucoseClinical Trials, Phase I as TopicClinical Trials, Phase II as TopicDiabetes Mellitus, Type 2Dose-Response Relationship, DrugDouble-Blind MethodErythrocytesFemaleHumansHypoglycemic AgentsMaleMiddle AgedModels, BiologicalBlood GlucoseHypoglycemic AgentsOligonucleotides, AntisenseAntisense oligonucleotidesGlucagon receptorGlucoseHbA1cRed blood cell lifespan modelType 2 diabetes mellitus

Identifiers

PMID28132162
OpenAlexW2580793886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.