ArticleCellular and molecular life sciences : CMLS2017
Membrane-traversing mechanism of thyroid hormone transport by monocarboxylate transporter 8.
Article in Cellular and molecular life sciences : CMLS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Novel SLC16A2 mutations impair thyroid hormone transport and drive neurodevelopmental deficits in Chinese patients with allan-herndon-dudley syndrome.Scientific reports · 2026Article
- Pathogenic MCT8V235L creates a steric clash that is alleviated by a compensating mutation of MCT8F285A.European thyroid journal · 2025Article
- Structural insights into thyroid hormone transporter MCT8.Nature communications · 2025Article
- Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs).Pharmaceutics · 2022Review
- Screening for drugs potentially interfering with MCT8-mediated TJournal of endocrinological investigation · 2022Article
- Clinical and Functional Consequences of C-Terminal Variants in MCT8: A Case Series.The Journal of clinical endocrinology and metabolism · 2021Article
- The Protein Translocation Defect of MCT8European thyroid journal · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocarboxylate transporter 8 (MCT8) mediates thyroid hormone (TH) transport across the plasma membrane in many cell types. In order to better understand its mechanism, we have generated three new MCT8 homology models based on sugar transporters XylE in the intracellular opened (PDB ID: 4aj4) and the extracellular partly occluded (PDB ID: 4gby) conformations as well as FucP (PDB ID: 3o7q) and GLUT3 (PDB ID: 4zwc) in the fully extracellular opened conformation. T
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Registered trials
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