Evidence map›Paper›PMID 28131907›Full record

ArticleMagnetic resonance imaging2017

3D late gadolinium enhanced cardiovascular MR with CENTRA-PLUS profile/view ordering: Feasibility of right ventricular myocardial damage assessment using a swine animal model.

Keigo Kawaji, Akiko Tanaka, Mita B Patel, Hui Wang, Francesco Maffessanti, Takeyoshi Ota, Amit R Patel

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Accelerated high-resolution free-breathing 3D whole-heart TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Keigo KawajiDepartment of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States. Electronic address: kkawaji@medicine.bsd.uchicago.edu.
Akiko TanakaDepartment of Radiology, The University of Chicago, Chicago, IL, United States.
Mita B PatelDepartment of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States.
Hui WangPhilips, Gainesville, FL, United States.
Francesco MaffessantiDepartment of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States.
Takeyoshi OtaDepartment of Radiology, The University of Chicago, Chicago, IL, United States.
Amit R PatelDepartment of Medicine, Section of Cardiology, The University of Chicago, Chicago, IL, United States; Department of Surgery, Section of Cardiothoracic Surgery, The University of Chicago, Chicago, IL, United States.
University of Chicago · USPhilips (Finland) · FI

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430
6 · The paper itself

Abstract

aimsTo develop a high-resolution, 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance imaging (MRI) technique for improved assessment of myocardial scars, and evaluate its performance against 2D breath-held (BH) LGE MRI using a surgically implanted animal scar model in the right ventricle (RV). METHODS AND

resultsA k-space segmented 3D LGE acquisition using CENTRA-PLUS (Contrast ENhanced Timing Robust Acquisition with Preparation of LongitUdinal Signal; or CP) ordering is proposed. 8 pigs were surgically prepared with cardiac patch implantation in the RV, followed in 60days by 1.5T MRI. LGE with Phase-Sensitive Inversion Recovery (PSIR) were performed as follows: 1) 2DBH using pneumatic control, and 2) navigator-gated, 3D free-breathing (3DFB)-CP-LGE with slice-tracking. The animal heart was excised immediately after cardiac MR for scar volume quantification. RV scar volumes were also delineated from the 2DBH and 3DFB-CP-LGE images for comparison against the surgical standard. Apparent scar/normal tissue signal-to-noise ratio (aSNR) and contrast-to-noise ratio (aCNR) were also calculated. 3DFB-CP-LGE technique was successfully performed in all animals. No difference in aCNR was noted, but aSNR was significantly higher using the 3D technique (p<0.05). Against the surgical reference volume, the 3DFB-CP-LGE-derived delineation yielded significantly less volume quantification error compared to 2DBH-derived volumes (15±10% vs 55±33%; p<0.05).

conclusionCompared to conventional 2DBH-LGE, 3DFB-LGE acquisition using CENTRA-PLUS provided superior scar volume quantification and improved aSNR.

Indexed as

AnimalsBreath HoldingContrast MediaDisease Models, AnimalFemaleGadoliniumHeartHeart VentriclesImaging, Three-DimensionalMagnetic Resonance ImagingMyocardial InfarctionMyocardiumRespirationSignal-To-Noise RatioSwineContrast MediaGadoliniumBreath-holdLate gadolinium enhancement MRIMyocardial infarctionNavigatorViability imaging

Identifiers

PMID28131907
PMCPMC5410402
OpenAlexW2581415156

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.