ReviewNeuroImage2017
From connectome to cognition: The search for mechanism in human functional brain networks.
Review in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- GINNA, a 33 resting-state networks atlas with meta-analytic decoding-based cognitive characterization.Communications biology · 2025Pooled it
- Meta-analytic evidence for a core problem solving network across multiple representational domains.Neuroscience and biobehavioral reviews · 2018Pooled it
- Estimating trial-wise modulation of functional connectivity using event-related fMRI.bioRxiv : the preprint server for biology · 2026Article
- Using connectome-based predictive models to reveal the systems standardized tests and clinical symptoms are reflecting.Nature communications · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia.Cerebellum (London, England) · 2026Article
- Cognition, but not affect, rests upon a segregated intrinsic network architecture.bioRxiv : the preprint server for biology · 2026Article
- Intrinsic ion dynamics underlies the temporal nature of resting-state functional connectivity.bioRxiv : the preprint server for biology · 2025Article
- Effective Connectivity Identifies Divergent Cerebro-Cerebellar Network Organization in Schizophrenia.Research square · 2025Article
- Improved whole-brain reconfiguration efficiency reveals mechanisms of speech rehabilitation in cleft lip and palate patients: an fMRI study.Frontiers in aging neuroscience · 2025Article
- Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.Cognitive, affective & behavioral neuroscience · 2024Article
- Task-specific topology of brain networks supporting working memory and inhibition.Human brain mapping · 2024Article
- Causation in neuroscience: keeping mechanism meaningful.Nature reviews. Neuroscience · 2024Review
- Rescuing missing data in connectome-based predictive modeling.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mechanisms of Change in Cognitive Function Domains Among Older Adults in Cognitive Deterioration and Improvement Groups: Evidence From Phenotypic Network Structure.Journal of the American Medical Directors Association · 2023Article
- Article
- Leading basic modes of spontaneous activity drive individual functional connectivity organization in the resting human brain.Communications biology · 2023Article
- Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research.Frontiers in network physiology · 2023Review
- Cortical connectivity gradients and local timescales during cognitive states are modulated by cognitive loads.Brain structure & function · 2022Article
- Network modeling of dynamic brain interactions predicts emergence of neural information that supports human cognitive behavior.PLoS biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Recent developments in functional connectivity research have expanded the scope of human neuroimaging, from identifying changes in regional activation amplitudes to detailed mapping of large-scale brain networks. However, linking network processes to a clear role in cognition demands advances in the theoretical frameworks, algorithms, and experimental approaches applied. This would help evolve the field from a descriptive to an explanatory state, by targeting network interactions that can mechanistically account for cognitive effects. In the present review, we provide an explicit framework to aid this search for "network mechanisms", which anchors recent methodological advances in functional connectivity estimation to a renewed emphasis on careful experimental design. We emphasize how this framework can address specific questions in network neuroscience. These span ambiguity over the cognitive relevance of resting-state networks, how to characterize task-evoked and spontaneous network dynamics, how to identify directed or "effective" connections, and how to apply multivariate pattern analysis at the network level. In parallel, we apply the framework to highlight the mechanistic interaction of network components that remain "stable" across task domains and more "flexible" components associated with on-task reconfiguration. By emphasizing the need to structure the use of diverse analytic approaches with sound experimentation, our framework promotes an explanatory mapping between the workings of the cognitive mind and the large-scale network mechanisms of the human brain.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.