ArticleNeuroImage2017
A neural network that links brain function, white-matter structure and risky behavior.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Relating Cognition to both Brain Structure and Function: A Systematic Review of Methods.Brain connectivity · 2023Pooled it
- Adaptations of the balloon analog risk task for neuroimaging settings: a systematic review.Frontiers in neuroscience · 2023Pooled it
- Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.Addiction biology · 2021Pooled it
- Longitudinal development of the anterior insula-nucleus accumbens white matter pathway through adolescence predicts risk taking in young adulthood.Developmental cognitive neuroscience · 2026Article
- Disentangling individual heterogeneity reveals robust network and molecular signatures of major depressive disorder with suicidal ideation.Translational psychiatry · 2026Article
- Diffusion connectometry reveals white matter substrates of individual differences in loss aversion.Scientific reports · 2025Article
- Age differences in the neural basis of decision-making under uncertainty.Cognitive, affective & behavioral neuroscience · 2023Article
- Effect of real-world fear on risky decision-making in medical school-based students: A quasi-experimental study.Frontiers in behavioral neuroscience · 2023Article
- Medication overuse headache and substance use disorder: A comparison based on basic research and neuroimaging.Frontiers in neurology · 2023Review
- Individual differences in frontoparietal plasticity in humans.NPJ science of learning · 2022Article
- Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting.NeuroImage. Clinical · 2022Article
- A generic brain connectome map linked to different types of everyday decision-making in old age.Brain structure & function · 2020Observational
- Associations between nucleus accumbens structural connectivity, brain function, and initiation of binge drinking.Addiction biology · 2020Article
- A Joint Modelling Approach to Analyze Risky Decisions by Means of Diffusion Tensor Imaging and Behavioural Data.Brain sciences · 2020Article
- Brain-Behavior Associations for Risk Taking Depend on the Measures Used to Capture Individual Differences.Frontiers in behavioral neuroscience · 2020Article
- Interpreting and Utilising Intersubject Variability in Brain Function.Trends in cognitive sciences · 2018Review
- Predicting risk decisions in a modified Balloon Analogue Risk Task: Conventional and single-trial ERP analyses.Cognitive, affective & behavioral neuroscience · 2018Article
- Neural underpinnings of maladaptive decision-making in addictions.Pharmacology, biochemistry, and behavior · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The ability to evaluate the balance between risk and reward and to adjust behavior accordingly is fundamental to adaptive decision-making. Although brain-imaging studies consistently have shown involvement of the dorsolateral prefrontal cortex, anterior insula and striatum during risky decision-making, activation in a neural network formed by these regions has not been linked to structural connectivity. Therefore, in this study, white-matter connectivity was measured with diffusion-weighted imaging in 40 healthy research participants who performed the Balloon Analogue Risk Task, a test of risky decision-making, during fMRI. Fractional anisotropy within a network that includes white-matter pathways connecting four regions (the prefrontal cortex, insula and midbrain to the striatum) was positively correlated with the number of risky choices and total amount earned on the task, and with the parametric modulation of activation in regions within the network to the level of risk during choice selection. Furthermore, analysis using a mixed model demonstrated how relationships of the parametric modulation of activation in each of the four aforementioned regions are related to risk probabilities, and how previous trial outcomes and task progression influence the choice to take risk. The present findings provide the first direct evidence that white-matter integrity is linked to function within previously identified components of a network that is activated during risky decision-making, and demonstrate that the integrity of white-matter tracts is critical in consolidating and processing signals between cortical and striatal circuits during the decision-making process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.