ArticleToxicology2017
Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.
Article in Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- The Multifaceted Role of Cytochrome P450 Isoenzymes in Alcoholic and Metabolic (Dysfunction) Fatty Liver Diseases.Current drug metabolism · 2026Review
- Molecular targets of PXR-dependent ethanol-induced hepatotoxicity in female mice.Biochemical pharmacology · 2024Article
- Review
- Interaction between fatty acid oxidation and ethanol metabolism in liver.American journal of physiology. Gastrointestinal and liver physiology · 2024Review
- Article
- A Review: Cytochrome P450 in Alcoholic and Non-Alcoholic Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism.Free radical biology & medicine · 2023Article
- Pathogenesis of Alcoholic Fatty Liver a Narrative Review.Life (Basel, Switzerland) · 2023Review
- Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass.Biochemical and biophysical research communications · 2022Article
- Review
- Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/Fgf21 signaling.Molecular biology reports · 2022Article
- PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.Biochemical pharmacology · 2021Article
- Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα.International journal of molecular sciences · 2021Review
- PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase.Free radical biology & medicine · 2021Article
- FGF21 in obesity and cancer: New insights.Cancer letters · 2021Review
- High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance.Annals of translational medicine · 2020Article
- CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model.International journal of obesity (2005) · 2019Article
- Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway.Frontiers in pharmacology · 2019Article
- Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.Archives of biochemistry and biophysics · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsCytochrome P450 2A5 (CYP2A5) is induced by ethanol, and the ethanol induction of CYP2A5 is regulated by nuclear factor-erythroid 2-related factor 2 (NRF2). Cyp2a5 knockout (Cyp2a5
methodsMice were fed the Lieber-Decarli ethanol diet to induce alcoholic fatty liver.
resultsMore severe alcoholic fatty liver disease was developed in Cyp2a5
conclusionsThese results suggest that CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARα-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.