Evidence map›Paper›PMID 28131816›Full record

ArticleThe Journal of investigative dermatology2017

TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.

Hiroyuki Yamamoto, Joohyun Ryu, Eli Min, Naomi Oi, Ruihua Bai, Tatyana A Zykova, Dong Hoon Yu, Kenji Moriyama, Ann M Bode, Zigang Dong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. NMolecular cancer · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. The relationship between TRAF6 and tumors.Cancer cell international · 2020
    Review
  10. Article
  11. Review
  12. TRAF1 Signaling in Human Health and Disease.Frontiers in immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hiroyuki YamamotoThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Joohyun RyuThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Eli MinThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Naomi OiThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Ruihua BaiThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Tatyana A ZykovaThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Dong Hoon YuThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Kenji MoriyamaDepartment of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Ann M BodeThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Zigang DongThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA. Electronic address: zgdong@hi.umn.edu.
University of Minnesota · USHormel (United States) · USMukogawa Women's University · JP

Funding

VITAMIN A, AND ITS PRECURSORS AND DERIVATIVES AS THERAPEUTIC MODALITIESP01CA027502 · NCI · UNIVERSITY OF ARIZONA · PI EINSPAHR, JANINE G · 1985 to 2015
$36.3M
Chemoprevention of colon cancer by targeting the Wnt/beta-catenin pathwayR01CA187027 · NCI · UNIVERSITY OF MINNESOTA · PI KANG, NINGLING, ROH, EUNMIRI · 2015 to 2019
$1.7M
Prevention of solar UV-induced skin cancer by targeting LTA4HR01CA196639 · NCI · UNIVERSITY OF MINNESOTA · PI LIU, LIANG · 2015 to 2019
$1.7M
Developing new ornithine decarboxylase inhibitors to prevent skin & colon cancerR01CA166011 · NCI · UNIVERSITY OF MINNESOTA · PI DONG, ZIGANG · 2013 to 2017
$1.6M
NCI NIH HHS P01 CA027502NCI NIH HHS R01 CA166011NCI NIH HHS R01 CA187027NCI NIH HHS R01 CA196639
6 · The paper itself

Abstract

TRAF1 is a member of the TRAF protein family, which regulates the canonical and noncanonical NF-κB signaling cascades. Although aberrant TRAF1 expression in tumors has been reported, the role of TRAF1 remains elusive. Here, we report that TRAF1 is required for solar UV-induced skin carcinogenesis. Immunohistochemical analysis showed that TRAF1 expression is up-regulated in human actinic keratosis and squamous cell carcinoma. In vivo studies indicated that TRAF1 expression levels in mouse skin are induced by short-term solar UV irradiation, and a long-term skin carcinogenesis study showed that deletion of TRAF1 in mice results in a significant inhibition of skin tumor formation. Moreover, we show that TRAF1 is required for solar UV-induced extracellular signal-regulated kinase-5 (ERK5) phosphorylation and the expression of AP-1 family members (c-Fos/c-Jun). Mechanistic studies showed that TRAF1 expression enhances the ubiquitination of ERK5 on lysine 184, which is necessary for its kinase activity and AP-1 activation. Overall, our results suggest that TRAF1 mediates ERK5 activity by regulating the upstream effectors of ERK5 and also by modulating its ubiquitination status. Targeting TRAF1 function might lead to strategies for preventing and treating skin cancer.

Indexed as

Gene Expression Regulation9,10-Dimethyl-1,2-benzanthraceneAnalysis of VarianceAnimalsCarcinogenesisCarcinoma, Squamous CellDisease Models, AnimalEpidermal CellsEpidermisGas Chromatography-Mass SpectrometryKeratinocytesKeratosis, ActinicMaleMiceMice, Inbred BALB CMitogen-Activated Protein Kinase 79,10-Dimethyl-1,2-benzanthraceneMitogen-Activated Protein Kinase 7TNF Receptor-Associated Factor 112-O-tetradecanoylphorbol-13-acetate7,12-dimethylbenz[a]anthraceneactinic keratosisadult human epidermal keratinocyteAKDMBAERKERK kinase 5extracellular signal-regulated protein kinaseHAHEKHEKahemagglutininhuman embryonic kidneyKkeratinMAPKMEK5mitogen-activated protein kinaseSCCsquamous cell carcinomaTPAwild typeWT

Identifiers

PMID28131816
PMCPMC5995119
OpenAlexW2580731741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.