Evidence map›Paper›PMID 28131630›Full record

ArticleJournal of molecular and cellular cardiology2017

The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca

Elisa Bovo, Sabine Huke, Lothar A Blatter, Aleksey V Zima

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 52 citations in OpenAlex.

  1. Ryanodine receptor cluster remodeling linksbioRxiv : the preprint server for biology · 2026
    Article
  2. The RyR-like-FKBP12-PKA Complex Regulates Intracellular CaInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Caveolae-associated cAMP/CaJournal of molecular and cellular cardiology · 2023
    Article
  9. Article
  10. Article
  11. Kinetics of the thapsigargin-induced CaFrontiers in physiology · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Elisa BovoDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, United States.
Sabine HukeMedicine-Division of Cardiovascular Disease, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, United States.
Lothar A BlatterDepartment of Molecular Biophysics and Physiology, Rush University Medical Center, 1750 West Harrison Street, Chicago, IL 60612, United States.
Aleksey V ZimaDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, United States. Electronic address: azima@luc.edu.
Loyola University Chicago · USRush University Medical Center · USUniversity of Alabama at Birmingham · US

Funding

Program AdministrationP01HL080101 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2006 to 2015
$23.4M
E/C COUPLING AND CALCIUM REGULATION IN ATRIAL MYOCYTESR01HL062231 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BLATTER, LOTHAR A · 1999 to 2012
$4.4M
MItochondrial Dysfunction in Cardiac Hypertrophy and FailureR01HL101235 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BERS, DONALD M, BLATTER, LOTHAR A · 2010 to 2013
$2.8M
Pathophysiological Regulation of Atrial Myocyte Excitation-Contraction Coupling and Calcium SignalingR01HL134781 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BLATTER, LOTHAR A · 2017 to 2020
$1.5M
Calcium release channel dysfunction: molecular mechanismsR01HL130231 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2016 to 2019
$1.5M
Pannexin channels in cardiac arrhythmiasR01HL128044 · NHLBI · VANDERBILT UNIVERSITY · PI KNOLLMANN, BJORN C, ZHOU, LUFANG · 2015 to 2018
$1.5M
NHLBI NIH HHS P01 HL080101NHLBI NIH HHS R01 HL062231NHLBI NIH HHS R01 HL101235NHLBI NIH HHS R01 HL128044NHLBI NIH HHS R01 HL130231NHLBI NIH HHS R01 HL134781
6 · The paper itself

Abstract

Functional impact of cardiac ryanodine receptor (type 2 RyR or RyR2) phosphorylation by protein kinase A (PKA) remains highly controversial. In this study, we characterized a functional link between PKA-mediated RyR2 phosphorylation level and sarcoplasmic reticulum (SR) Ca

Indexed as

Ion Channel GatingAnimalsCalciumCalcium SignalingCyclic AMPCyclic AMP-Dependent Protein KinasesHeart VentriclesMyocardiumMyocytes, CardiacPhosphorylationRabbitsRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumCalciumCyclic AMPCyclic AMP-Dependent Protein KinasesRyanodine Receptor Calcium Release ChannelCa(2+) sparkCardiomyocyteProtein kinase AProtein phosphatasesRyanodine receptorSarcoplasmic reticulum Ca(2+) leak

Identifiers

PMID28131630
PMCPMC5337148
OpenAlexW2580528329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.