ArticleBrain stimulation
Temporal plasticity in auditory cortex improves neural discrimination of speech sounds.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Vagus nerve stimulation rescues impaired fear extinction and social interaction in a rat model of autism spectrum disorder.Journal of affective disorders · 2025Article
- Mechanism and Applications of Vagus Nerve Stimulation.Current issues in molecular biology · 2025Review
- Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission.Frontiers in neural circuits · 2025Review
- Vagus nerve stimulation during training fails to improve learning in healthy rats.Scientific reports · 2024Article
- Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing.Frontiers in neuroscience · 2023Article
- Direct and Transcutaneous Vagus Nerve Stimulation for Treatment of Tinnitus: A Scoping Review.Frontiers in neuroscience · 2021Article
- Restoration of Somatosensory Function by Pairing Vagus Nerve Stimulation with Tactile Rehabilitation.Annals of neurology · 2020Article
- Short-Term Effects of Vagus Nerve Stimulation on Learning and Evoked Activity in Auditory Cortex.eNeuroArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundMany individuals with language learning impairments exhibit temporal processing deficits and degraded neural responses to speech sounds. Auditory training can improve both the neural and behavioral deficits, though significant deficits remain. Recent evidence suggests that vagus nerve stimulation (VNS) paired with rehabilitative therapies enhances both cortical plasticity and recovery of normal function. OBJECTIVE/HYPOTHESIS: We predicted that pairing VNS with rapid tone trains would enhance the primary auditory cortex (A1) response to unpaired novel speech sounds.
methodsVNS was paired with tone trains 300 times per day for 20 days in adult rats. Responses to isolated speech sounds, compressed speech sounds, word sequences, and compressed word sequences were recorded in A1 following the completion of VNS-tone train pairing.
resultsPairing VNS with rapid tone trains resulted in stronger, faster, and more discriminable A1 responses to speech sounds presented at conversational rates.
conclusionThis study extends previous findings by documenting that VNS paired with rapid tone trains altered the neural response to novel unpaired speech sounds. Future studies are necessary to determine whether pairing VNS with appropriate auditory stimuli could potentially be used to improve both neural responses to speech sounds and speech perception in individuals with receptive language disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.