Evidence map›Paper›PMID 28131433›Full record

Trial reportPsychiatry research2018

The effect of mindfulness meditation training on biological acute stress responses in generalized anxiety disorder.

Elizabeth A Hoge, Eric Bui, Sophie A Palitz, Noah R Schwarz, Maryann E Owens, Jennifer M Johnston, Mark H Pollack, Naomi M Simon

2 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychiatry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 80 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 7 pooled it
23.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03622697 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Mindfulness Meditation to Improve Social Functioning and Quality of Life in Patients With Facial Paralysis: A Randomized Controlled Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2021 to 2022Enrolled0ConditionsFacial ParalysisArmsMindfulness Meditation Phone Application
NCT06017765 narecruitingnot on this mapstarted 2023, after this paper: background citation

Coping After Loss Through Mindfulness Training in Grieving Adults With Prolonged Grief Disorder - A Neuroimaging Pilot Study

TypeinterventionalSponsorUniversity Hospital, CaenRan2023 to 2026Enrolled30ConditionsProlonged Grief DisorderArmsMeditation Training, Waitlist
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 7 syntheses or guidelines pooled it, 193 citations in OpenAlex.

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  13. Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Elizabeth A HogeCenter for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Georgetown University Medical Center, Washington, DC, USA. Electronic address: eah103@georgetown.edu.
Eric BuiCenter for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Sophie A PalitzCenter for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Noah R SchwarzCenter for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Maryann E OwensCenter for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Jennifer M JohnstonDepartment of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Mark H PollackDepartment of Psychiatry, Rush University Medical Center, Chicago, IL, USA.
Naomi M SimonCenter for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Massachusetts General Hospital · USBoston University · USGeorgetown University · USRush University Medical Center · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
MBSR and Anxiety: Therapeutic and Neuroendocrine EffectsK23AT004432 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HOGE, ELIZABETH A · 2008 to 2013
$698k
NCCIH NIH HHS K23 AT004432NCCIH NIH HHS L30 AT005427NCRR NIH HHS UL1 RR025758
6 · The paper itself

Abstract

Mindfulness-Based interventions have increased in popularity in psychiatry, but the impact of these treatments on disorder-relevant biomarkers would greatly enhance efficacy and mechanistic evidence. If Generalized Anxiety Disorder (GAD) is successfully treated, relevant biomarkers should change, supporting the impact of treatment and suggesting improved resilience to stress. Seventy adults with GAD were randomized to receive either Mindfulness-Based Stress Reduction (MBSR) or an attention control class; before and after, they underwent the Trier Social Stress Test (TSST). Area-Under-the-Curve (AUC) concentrations were calculated for adrenocorticotropic hormone (ACTH) and pro-inflammatory cytokines. MBSR participants had a significantly greater reduction in ACTH AUC compared to control participants. Similarly, the MBSR group had a greater reduction in inflammatory cytokines' AUC concentrations. We found larger reductions in stress markers for patients with GAD in the MBSR class compared to control; this provides the first combined hormonal and immunological evidence that MBSR may enhance resilience to stress.

Indexed as

MindfulnessAdaptation, PsychologicalAdrenocorticotropic HormoneAdultAnxiety DisordersArousalFemaleHumansInterleukin-6MaleMeditationMiddle AgedStress, PsychologicalTumor Necrosis Factor-alphaAdrenocorticotropic HormoneInterleukin-6Tumor Necrosis Factor-alphaAcute stressAnxietyMeditationMindfulness-based interventionPsychological stressResilienceStress reactivity

Identifiers

PMID28131433
PMCPMC5526744
OpenAlexW2581630748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.