Evidence map›Paper›PMID 28131278›Full record

ArticleMolecular therapy. Nucleic acids2016

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases.

Carmen F Bjurström, Michelle Mojadidi, John Phillips, Caroline Kuo, Stephen Lai, Georgia R Lill, Aaron Cooper, Michael Kaufman, Fabrizia Urbinati, Xiaoyan Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  10. Article
  11. Article
  12. Review
  13. Review
  14. Gene editing and its applications in biomedicine.Science China. Life sciences · 2022
    Review
  15. Article
  16. Advancing the care of β-thalassaemia patients with novel therapies.Blood transfusion = Trasfusione del sangue · 2022
    Review
  17. Review
  18. Article
  19. Curative gene therapies for rare diseases.Journal of community genetics · 2021
    Article
  20. CRISPR/Cas-Dependent and Nuclease-FreeHuman gene therapy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Carmen F BjurströmDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Michelle MojadidiDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
John PhillipsHoward Hughes Medical Institute, University of California, Los Angeles, Los Angeles, California, USA.
Caroline KuoDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, California, USA.
Stephen LaiDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Georgia R LillDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Aaron CooperDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Michael KaufmanDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Fabrizia UrbinatiDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Xiaoyan WangDepartment of General Internal Medicine and Health Services Research, University of California, Los Angeles, Los Angeles, California, USA.
Roger P HollisDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Donald B KohnDepartment of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA; Department of Pediatrics, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: dkohn@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Transduction of Human Stem and Progenitor CellsP01HL073104 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2003 to 2013
$18.3M
NHLBI NIH HHS P01 HL073104NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to target the gene encoding the transcriptional repressor BCL11A, in human K562 cells and human CD34

Indexed as

BCL11ACRISPR/Cas9fetal hemoglobinnonhomologous end joiningTALENszinc finger nucleases

Identifiers

PMID28131278
PMCPMC5023398
OpenAlexW2511405152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.