Evidence map›Paper›PMID 28131126›Full record

ReviewEndocrinology and metabolism clinics of North America2017

The Role of the Osteocyte in Bone and Nonbone Disease.

Lynda F Bonewald

Abstract readReview
In one paragraph

Review in Endocrinology and metabolism clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Effects of progesterone therapy on serum sclerostin levels in healthy menopausal women: a 3-month randomized, placebo-controlled clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
    Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Heart Failure and Osteoporosis: Shared Challenges in the Aging Population.Journal of cardiovascular development and disease · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Lynda F BonewaldIndiana Center for Musculoskeletal Health, VanNuys Medical Science Building, MS 5055, 635 Barnhill Drive, Indianapolis, IN 46202, USA; Department of Anatomy and Cell Biology, VanNuys Medical Science Building, MS 5035, Indianapolis, IN 46202, USA; Department of Orthopaedic Surgery, 1120 West Michigan Street, Suite 600, Indianapolis, IN 46202, USA. Electronic address: lbonewal@iu.edu.

Funding

Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3M
NIA NIH HHS P01 AG039355
6 · The paper itself

Abstract

When normal physiologic functions go awry, disorders and disease occur. This is universal; even for the osteocyte, a cell embedded within the mineralized matrix of bone. It was once thought that this cell was simply a placeholder in bone. Within the last decade, the number of studies of osteocytes has increased dramatically, leading to the discovery of novel functions of these cells. With the discovery of novel physiologic functions came the discoveries of how these cells can also be responsible for not only bone diseases and disorders, but also those of the kidney, heart, and potentially muscle.

Indexed as

Bone and BonesBone DiseasesFibroblast Growth Factor-23Heart DiseasesHumansKidney DiseasesMuscular DiseasesOsteocytesFibroblast Growth Factor-23Bone diseaseFGF23OsteocyteSclerostinTherapeutics

Identifiers

PMID28131126
PMCPMC5300041

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.