ArticleNeurobiology of aging2017
Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03972202 (The Role of Cerebellum in Speech), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cerebellum in Speech
Who cites it
37 citing papers in PubMed, 57 citations in OpenAlex.
- A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.Scientific reports · 2024Trial
- SpeechDETECT: an explainable automated speech processing pipeline for early detection of neurological and health changes.Health information science and systems · 2026Article
- Probing the role of left inferior frontal gyrus in vocal motor control: Evidence from TMS and causal inference analysis.iScience · 2026Article
- Integrating acoustic, prosodic, and phonological features for automatic Alzheimer's detection.Frontiers in aging neuroscience · 2026Article
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Enhanced pitch centering in individuals with laryngeal dystonia.Frontiers in human neuroscience · 2026Article
- Phase-Specific Contributions and Interactions of the Left and Right Posterior Middle Temporal Gyri in Vocal Feedback Control: Evidence From Dual-Site TMS.Human brain mapping · 2025Article
- Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior.Neurobiology of aging · 2025Article
- Bayesian inference of state feedback control parameters for fo perturbation responses in cerebellar ataxia.PLoS computational biology · 2024Article
- Segmental and Suprasegmental Speech Foundation Models for Classifying Cognitive Risk Factors: Evaluating Out-of-the-Box Performance.Interspeech · 2024Article
- Socioemotional dysfunction and the greater good: a case study.Neurocase · 2024Article
- Impairment of the internal forward model and feedback mechanisms for vocal sensorimotor control in post-stroke aphasia: evidence from directional responses to altered auditory feedback.Experimental brain research · 2024Article
- Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease.Frontiers in human neuroscience · 2024Article
- Article
- Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation.Frontiers in neuroscience · 2023Article
- Aging-related decline in the neuromotor control of speech production: current and future.Frontiers in aging neuroscience · 2023Article
- Early ultrasonic vocalization deficits and related thyroarytenoid muscle pathology in the transgenic TgF344-AD rat model of Alzheimer's disease.Frontiers in behavioral neuroscience · 2023Article
- Continuous theta burst stimulation over right cerebellum for speech impairment in Parkinson's disease: study protocol for a randomized, sham-controlled, clinical trial.Frontiers in aging neuroscience · 2023Article
- Early auditory responses to speech sounds in Parkinson's disease: preliminary data.Scientific reports · 2022Article
- Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.Brain communications · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Speakers respond automatically and rapidly to compensate for brief perturbations of pitch in their auditory feedback. The specific adjustments in vocal output require integration of brain regions involved in speech-motor-control in order to detect the sensory-feedback error and implement the motor correction. Cortical regions involved in the pitch reflex phenomenon are highly vulnerable targets of network disruption in Alzheimer's disease (AD). We examined the pitch reflex in AD patients (n = 19) compared to an age-matched control group (n = 16). We measured the degree of behavioral compensation (peak compensation) and the extent of the adaptive response (pitch-response persistence). Healthy-controls reached a peak compensation of 18.7 ± 0.8 cents, and demonstrated a sustained compensation at 8.9 ± 0.69 cents. AD patients, in contrast, demonstrated a significantly elevated peak compensation (22.4 ± 1.2 cents, p < 0.05), and a reduced sustained response (pitch-response persistence, 4.5 ± 0.88 cents, p < 0.001). The degree of increased peak compensation predicted executive dysfunction, while the degree of impaired pitch-response persistence predicted memory dysfunction, in AD patients. The current study demonstrates pitch reflex as a sensitive behavioral index of impaired prefrontal modulation of sensorimotor integration, and compromised plasticity mechanisms of memory, in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.