ArticleHuman brain mapping2017
The human subthalamic nucleus and globus pallidus internus differentially encode reward during action control.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Measuring Subthalamic Nucleus Volume of Parkinson's Patients and Evaluating Its Relationship with Clinical Scales at Pre- and Postdeep Brain Stimulation Treatment: A Magnetic Resonance Imaging Study.BioMed research international · 2021Trial
- Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation.Nature communications · 2026Article
- Electrophysiology and Functional Magnetic Resonance Imaging of Cue Craving: Potential Biomarkers for Therapeutic Neuromodulation in Addiction.Biological psychiatry global open science · 2026Review
- Article
- Focused stimulation of dorsal versus ventral subthalamic nucleus enhances action-outcome learning in patients with Parkinson's disease.Brain communications · 2024Article
- Uncovering the neurophysiology of mood, motivation and behavioral symptoms in Parkinson's disease through intracranial recordings.NPJ Parkinson's disease · 2023Review
- Article
- Subthalamic Oscillatory Activity of Reward and Loss Processing Using the Monetary Incentive Delay Task in Parkinson Disease.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Distinct Roles of the Human Subthalamic Nucleus and Dorsal Pallidum in Parkinson's Disease Impulsivity.Biological psychiatry · 2022Article
- Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Independent support for corticopallidal contributions to schizophrenia-related functional impairment.Schizophrenia research · 2020Article
- Intrinsic Connectivity of the Globus Pallidus: An Uncharted Marker of Functional Prognosis in People With First-Episode Schizophrenia.Schizophrenia bulletin · 2020Article
- Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery.Brain sciences · 2019Article
- Errors in Action Timing and Inhibition Facilitate Learning by Tuning Distinct Mechanisms in the Underlying Decision Process.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Subthalamic Nucleus: Unravelling New Roles and Mechanisms in the Control of Action.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- A review of basal ganglia circuits and physiology: Application to deep brain stimulation.Parkinsonism & related disorders · 2019Review
- Article
- Non-motor Characterization of the Basal Ganglia: Evidence From Human and Non-human Primate Electrophysiology.Frontiers in neuroscience · 2018Review
- Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.Parkinson's disease · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subthalamic nucleus (STN) and globus pallidus internus (GPi) have recently been shown to encode reward, but few studies have been performed in humans. We investigated STN and GPi encoding of reward and loss (i.e., valence) in humans with Parkinson's disease. To test the hypothesis that STN and GPi neurons would change their firing rate in response to reward- and loss-related stimuli, we recorded the activity of individual neurons while participants performed a behavioral task. In the task, action choices were associated with potential rewarding, punitive, or neutral outcomes. We found that STN and GPi neurons encode valence-related information during action control, but the proportion of valence-responsive neurons was greater in the STN compared to the GPi. In the STN, reward-related stimuli mobilized a greater proportion of neurons than loss-related stimuli. We also found surprising limbic overlap with the sensorimotor regions in both the STN and GPi, and this overlap was greater than has been previously reported. These findings may help to explain alterations in limbic function that have been observed following deep brain stimulation therapy of the STN and GPi. Hum Brain Mapp 38:1952-1964, 2017. © 2017 Wiley Periodicals, Inc.
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