Observational studyEpilepsia2017
Time to electroencephalography is independently associated with outcome in critically ill neonates and children.
Observational study in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Point-of-care EEG in the pediatric emergency department: a systematic review.European journal of pediatrics · 2025Pooled it
- Guidance for clinical neurophysiology examination throughout the COVID-19 pandemic. Latin American chapter of the IFCN task force - COVID-19.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Guideline
- Machine Learning Using Electroencephalography Predicts Acute Cerebral Injury in the Pediatric ICU.Neurocritical care · 2026Article
- Point-of-Care EEG Artificial Intelligence Measure of Seizure Burden Associates With Clinical Outcome at Discharge.Critical care medicine · 2026Article
- EEG in patients with altered mental status in the emergency department.International journal of emergency medicine · 2026Article
- E-Learning for Pediatric Emergency Department Staff in Point-of-Care Electroencephalogram Interpretation: Prospective Cohort Study.JMIR medical education · 2025Article
- Late-Onset Findings During Extended EEG Monitoring Are Rare in Critically Ill Children.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Article
- The Cost of After-Hour Electroencephalography.Neurology. Clinical practice · 2024Article
- Continuous electroencephalography in the intensive care unit: A critical review and position statement from an Australian and New Zealand perspective.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Article
- The Role of Electroencephalography in the Prognostication of Clinical Outcomes in Critically Ill Children: A Review.Children (Basel, Switzerland) · 2022Review
- Amplitude-Integrated EEG Monitoring in Pediatric Intensive Care: Prognostic Value in Meningitis before One Year of Age.Children (Basel, Switzerland) · 2022Article
- Review
- Machine learning models to predict electroencephalographic seizures in critically ill children.Seizure · 2021Observational
- Continuous EEG in a Pediatric Intensive Care Unit: Adherence to Monitoring Criteria and Barriers to Adequate Implementation.Neurocritical care · 2021Article
- Assessment of a Study of Continuous vs Repeat-Spot Electroencephalography in Patients With Critical Illness.JAMA neurology · 2021Article
- Characterization of aEEG During Sleep and Wakefulness in Healthy Children.Frontiers in pediatrics · 2021Article
- EEG monitoring duration to identify electroencephalographic seizures in critically ill children.Neurology · 2020Observational
- aEEG Use in Pediatric Critical Care-An Online Survey.Frontiers in pediatrics · 2020Article
- Amplitude-Integrated EEG for Neurological Assessment and Seizure Detection in a German Pediatric Intensive Care Unit.Frontiers in pediatrics · 2019Article
- Rapid Bedside Evaluation of Seizures in the ICU by Listening to the Sound of Brainwaves: A Prospective Observational Clinical Trial of Ceribell's Brain Stethoscope Function.Neurocritical care · 2018Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo identify factors associated with in-hospital mortality in neonates and children undergoing continuous electroencephalography (cEEG) monitoring in the intensive care unit (ICU).
methodsWe performed a retrospective observational study in patients from birth to 21 years of age who underwent clinically indicated cEEG in the ICU from 2011 to 2013. The main outcome measure was in-hospital mortality.
resultsSix-hundred and twenty-five patients (54.2% male) met eligibility criteria, of whom 211 were neonates (55% male, 24.8% premature) and 414 were pediatric patients (53.9% male). Electrographic seizures occurred in 176 patients (28.2%) and status epilepticus (SE) occurred in 20 (11.4%). The time from ICU admission to cEEG initiation was 16.7 (5.1-94.4) h. Eighty-nine patients (14.2%) (30 [14.2%] neonates, and 59 [14.3%] pediatric patients) died in the hospital. In neonates-after controlling for gender and prematurity-independent factors associated with mortality were prematurity (odds ratio [OR] 2.63. 95% confidence interval [CI] 1.06-6.5, p = 0.037), presence of status epilepticus (SE); OR 8.82, 95% CI 1.74-44.57, p = 0.008), and time from ICU admission to initiation of cEEG (OR 1.002, 95% CI 1.001-1.004 per hour, p = 0.008]. In pediatric patients-after controlling for gender and age-independent factors associated with mortality were the absence of seizures factors associated with mortality were absence of seizures (OR = 4.3, (95% CI: 1.5-12.4), p = 0.007), the presence of SE (OR 7.76, 95% CI 1.47-40.91, p = 0.016), and the time from ICU admission to initiation of cEEG (OR 1.001, 95% CI 1.0002-1.001, per hour, p = 0.005]. SIGNIFICANCE: Both presence of electrographic SE and time from ICU admission to cEEG initiation were independent factors associated with mortality in neonates and pediatric patients with cEEG in the ICU.
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