Evidence map›Paper›PMID 28130756›Full record

ArticleMolecular diagnosis & therapy2017

Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.

Claire Franczak, Julia Salleron, Cindy Dubois, Pierre Filhine-Trésarrieu, Agnès Leroux, Jean-Louis Merlin, Alexandre Harlé

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Article in Molecular diagnosis & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Molecular genetic and immunotherapeutic targets in metastatic melanoma.Virchows Archiv : an international journal of pathology · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Claire FranczakInstitut de Cancérologie de Lorraine, Service de Biopathologie, 6 Avenue de Bourgogne, CS 30519, 54 519, Vandoeuvre-lès-Nancy Cedex, France.
Julia SalleronUniversité de Lorraine, Nancy, France.
Cindy DuboisInstitut de Cancérologie de Lorraine, Service de Biopathologie, 6 Avenue de Bourgogne, CS 30519, 54 519, Vandoeuvre-lès-Nancy Cedex, France.
Pierre Filhine-TrésarrieuInstitut de Cancérologie de Lorraine, Service de Biopathologie, 6 Avenue de Bourgogne, CS 30519, 54 519, Vandoeuvre-lès-Nancy Cedex, France.
Agnès LerouxUniversité de Lorraine, Nancy, France.
Jean-Louis MerlinUniversité de Lorraine, Nancy, France.
Alexandre HarléUniversité de Lorraine, Nancy, France. a.harle@nancy.unicancer.fr.
Institut de Cancérologie de Lorraine · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastatic or unresectable melanoma is a serious and deadly disease. Anti-BRAF and immunotherapy improved overall survival in patients with metastatic disease. Thus, BRAF genotyping is important to choose the right therapy.

methodsIn our study, we assessed and compared BRAF mutations in 59 formalin-fixed and paraffin-embedded tumor samples of patients with metastatic melanoma with next-generation sequencing (NGS), Cobas

resultsThirty-one samples were found bearing a BRAF mutation with NGS (52.5%), 28 with Cobas

Indexed as

MutationAllelesDNA Mutational AnalysisFemaleGenotypeHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryMaleMelanomaNeoplasm MetastasisNeoplasm StagingPolymerase Chain ReactionProto-Oncogene Proteins B-rafSensitivity and SpecificityProto-Oncogene Proteins B-raf

Identifiers

PMID28130756
OpenAlexW2581476011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.