ArticleBrain imaging and behavior2018
Effects of social adversity and HIV on subcortical shape and neurocognitive function.
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Resting-state neural signatures of depressive symptoms in acute HIV.Journal of neurovirology · 2020Trial
- Effects of HIV and Adverse Childhood Experiences on Neurocognition.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Beyond Acculturation: Contextual Factors Predicting Neurocognitive Performance in a Clinical Sample of Latina/o/e Adults.AIDS education and prevention : official publication of the International Society for AIDS Education · 2025Article
- The relationship between social network size and brain structure in older adults living with HIV.Brain imaging and behavior · 2025Article
- Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.Brain sciences · 2024Article
- Psychological grit moderates the relation between lifetime stressor exposure and functional outcomes among HIV-seropositive and HIV-seronegative adults.Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?The Journal of infectious diseases · 2023Article
- Neural correlates of verbal fluency revealed by longitudinal T1, T2 and FLAIR imaging in stroke.NeuroImage. Clinical · 2023Article
- The neurocognitive implications of depression and socioeconomic status in people with HIV.Journal of clinical and experimental neuropsychology · 2022Article
- Evidence for neuropsychological health disparities in Black Americans with HIV disease.The Clinical neuropsychologist · 2022Article
- Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure.Frontiers in neuroscience · 2022Article
- Daily Cannabis Use is Associated With Lower CNS Inflammation in People With HIV.Journal of the International Neuropsychological Society : JINS · 2021Article
- Mini-review: Elucidating the psychological, physical, and sex-based interactions between HIV infection and stress.Neuroscience letters · 2021Review
- Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV.JAMA network open · 2021Article
- Cultural Neuropsychology Considerations in the Diagnosis of HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Article
- Reflections on Neurofeminism and Intersectionality Using Insights From Psychology.Frontiers in human neuroscience · 2021Review
- Family Income Mediates the Effect of Parental Education on Adolescents' Hippocampus Activation During an N-Back Memory Task.Brain sciences · 2020Article
- Brain structural correlates of trajectories to cognitive impairment in men with and without HIV disease.Brain imaging and behavior · 2020Article
- Experienced discrimination and racial differences in leukocyte gene expression.Psychoneuroendocrinology · 2019Article
- Effects of trauma, economic hardship, and stress on neurocognition and everyday function in HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The purpose of the current study was to examine the independent and interactive effects of social adversity (SA) and HIV infection on subcortical shape alterations and cognitive functions. Participants included HIV+ (n = 70) and HIV- (n = 23) individuals who underwent MRI, neurocognitive and clinical assessment, in addition to completing questionnaires from which responses were used to create an SA score. Bilateral amygdalae and hippocampi were extracted from T1-weighted images. Parametric statistical analyses were used to compare the radial distance of the structure surface to a median curve to determine the presence of localized shape differences as a function of HIV, SA and their interaction. Next, multiple regression was used to examine the interactive association between HIV and SA with cognitive performance data. An HIV*SA interactive effect was found on the shape of the right amygdala and left hippocampus. Specifically, HIV-infected participants (but not HIV-uninfected controls) who evidenced higher levels of SA displayed an inward deformation of the surface consistent with reduced volume of these structures. We found interactive effects of HIV and SA on learning/memory performance. These results suggest that HIV+ individuals may be more vulnerable to neurological and cognitive changes in the hippocampus and amygdala as a function of SA than HIV- individuals, and that SA indicators of childhood SES and perceived racial discrimination are important components of adversity that are associated with cognitive performance.
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Registered trials
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