Evidence map›Paper›PMID 28130737›Full record

SynthesisSleep & breathing = Schlaf & Atmung2017

Dexmedetomidine versus propofol during drug-induced sleep endoscopy and sedation: a systematic review.

Edward T Chang, Victor Certal, Sungjin A Song, Soroush Zaghi, Marina Carrasco-Llatas, Carlos Torre, Robson Capasso, Macario Camacho

Registry-linked trialAbstract readComparative StudySystematic Review
PubMed Publisher
In one paragraph

Synthesis in Sleep & breathing = Schlaf & Atmung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06756594 (Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation During Gastrointestinal Endoscopy), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06756594 nacompletednot on this mapstarted 2024, after this paper: background citation

Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation During Gastrointestinal Endoscopy

TypeinterventionalSponsorSohag UniversityRan2024 to 2025Enrolled100ConditionsPropofolArmsDexmedetomidine-Propofol, Ketamine-Propofol
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  5. Review
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edward T ChangDivision of Otolaryngology-Head and Neck Surgery, Tripler Army Medical Center, 1 Jarrett White Rd, Honolulu, HI, 96859, USA. etchan78@gmail.com.
Victor CertalDepartment of Otorhinolaryngology/Sleep Medicine Centre, Hospital CUF, Porto, Portugal.
Sungjin A SongDivision of Otolaryngology-Head and Neck Surgery, Tripler Army Medical Center, 1 Jarrett White Rd, Honolulu, HI, 96859, USA.
Soroush ZaghiDepartment of Otolaryngology-Head and Neck Surgery Division of Sleep Surgery and Medicine, Stanford Hospital and Clinics, Stanford, CA, USA.
Marina Carrasco-LlatasDepartment of Otolaryngology-Head and Neck Surgery, Hospital Universitario Doctor Peset, 46017, Valencia, Spain.
Carlos TorreDepartment of Otolaryngology-Head and Neck Surgery Miller School of Medicine, University of Miami, Miami, FL, USA.
Robson CapassoDepartment of Otolaryngology-Head and Neck Surgery Division of Sleep Surgery and Medicine, Stanford Hospital and Clinics, Stanford, CA, USA.
Macario CamachoDepartment of Otolaryngology-Head and Neck Surgery Division of Sleep Surgery and Medicine, Stanford Hospital and Clinics, Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of the present study is to review the international literature, using a systematic review, for studies comparing propofol and dexmedetomidine for drug-induced sleep endoscopy (DISE) or sedation in which there is a description of the effect of the agents on the upper airway and associated variables (e.g., vital signs, sedation scores).

methodsThis is a systematic review through October 4, 2016. PubMed/MEDLINE and four additional databases were accessed for this study.

resultsTwo hundred twenty studies were screened, 79 were downloaded, and 10 met criteria. The majority of the studies identified dexmedetomidine as the preferred pharmacologic agent for DISE due to an overall safer and more stable profile based upon hemodynamic stability. However, propofol provided greater airway obstruction with oxygen desaturations. With either agent, the degree of obstruction in the upper airway lacks some degree of validity as to whether the obstructions accurately represent natural sleep or are simply a drug-induced effect.

conclusionDexmedetomidine and propofol have their advantages and disadvantages during DISE. Generally, dexmedetomidine was preferred and seemed to provide a more stable profile based upon cardiopulmonary status. However, propofol has a quicker onset, has a shorter half-life, and can demonstrate larger degrees of obstruction, which might more accurately reflect what happens during REM sleep. Additional research is recommended.

Indexed as

AnesthesiaDexmedetomidineEndoscopyHumansPropofolSleepDexmedetomidinePropofolDexmedetomidineDISEObstructive sleep apnea (OSA)PropofolSleep apnea syndromesSystematic review

Identifiers

PMID28130737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.