Evidence map›Paper›PMID 28130614›Full record

ArticleJournal of muscle research and cell motility2016

Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only.

Giorgia Valle, Barbara Vergani, Roberta Sacchetto, Carlo Reggiani, Edith De Rosa, Lisa Maccatrozzo, Alessandra Nori, Antonello Villa, Pompeo Volpe

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of muscle research and cell motility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Ablation of Calsequestrin-1, CaFrontiers in physiology · 2022
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Giorgia ValleDipartimento di Scienze Biomediche dell'Università di Padova, Istituto Interuniversitario di Miologia, Viale G. Colombo 3, 35121, Padova, Italy.
Barbara VerganiConsorzio MIA (Microscopy Image Analysis), Università di Milano-Bicocca, 20052, Monza, Italy.
Roberta SacchettoDipartimento di Biomedicina Comparata ed Alimentazione dell'Università di Padova, Padova, Italy.
Carlo ReggianiDipartimento di Scienze Biomediche dell'Università di Padova, Istituto Interuniversitario di Miologia, Viale G. Colombo 3, 35121, Padova, Italy.
Edith De RosaDipartimento di Scienze Biomediche dell'Università di Padova, Istituto Interuniversitario di Miologia, Viale G. Colombo 3, 35121, Padova, Italy.
Lisa MaccatrozzoDipartimento di Biomedicina Comparata ed Alimentazione dell'Università di Padova, Padova, Italy.
Alessandra NoriDipartimento di Scienze Biomediche dell'Università di Padova, Istituto Interuniversitario di Miologia, Viale G. Colombo 3, 35121, Padova, Italy.
Antonello VillaConsorzio MIA (Microscopy Image Analysis), Università di Milano-Bicocca, 20052, Monza, Italy.
Pompeo VolpeDipartimento di Scienze Biomediche dell'Università di Padova, Istituto Interuniversitario di Miologia, Viale G. Colombo 3, 35121, Padova, Italy. pompeo.volpe@unipd.it.ORCID 0000-0003-0151-1585
University of Padua · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2-/- mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2-/- mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum.

Indexed as

AnimalsCalcium-Binding ProteinsCalsequestrinMaleMiceMice, Inbred C57BLMice, KnockoutMuscle ProteinsMuscle, SkeletalSarcoplasmic ReticulumCalcium-Binding ProteinsCalsequestrincasq2 protein, mouseMuscle ProteinsAdaptationCalsequestrinKnock-out miceSkeletal muscle

Identifiers

PMID28130614
OpenAlexW2581191402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.