ArticleInternational journal of colorectal disease2017
Functional outcome following rectal surgery-predisposing factors for low anterior resection syndrome.
Article in International journal of colorectal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06036862 (A Prospective Clinical Study of Transanal and Transabdominal Combined Endoscopic Resection of Rectal Stenosis and Anal Reconstruction for Severe Rectal Anastomotic Stenosis), which is not on this map. Cited by 76 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Clinical Study of Transanal and Transabdominal Combined Endoscopic Resection of Rectal Stenosis and Anal Reconstruction for Severe Rectal Anastomotic Stenosis
Who cites it
76 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Association between anastomotic leak after rectal resection and bowel dysfunction, a systematic review, meta-analysis and meta-regression.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- A systematic review of preoperative radiological factors associated with the development of low anterior resection syndrome (LARS).Updates in surgery · 2025Pooled it
- Early versus delayed defunctioning ileostomy closure after low anterior resection for rectal cancer: a meta-analysis and trial sequential analysis of safety and functional outcomes.International journal of colorectal disease · 2022Pooled it
- Colonic J-pouch versus side-to-end anastomosis for rectal cancer: a systematic review and meta-analysis of randomized controlled trials.BMC surgery · 2021Pooled it
- Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis.Techniques in coloproctology · 2021Pooled it
- A meta-analysis of the role of diverting ileostomy after rectal cancer surgery.International journal of colorectal disease · 2021Pooled it
- Systematic review of robotic low anterior resection for rectal cancer.Surgical endoscopy · 2018Pooled it
- Impact of neoadjuvant treatment on functional outcomes after transanal total mesorectal excision (taTME)-a case series.Surgical endoscopy · 2025Trial
- A multicentre prospective study of anal function after laparoscopic ultra-low rectal cancer surgery using a mixed-effects model.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Trial
- "Prophylactic" transanal irrigation (TAI) to prevent symptoms of low anterior resection syndrome (LARS) after rectal resection: results at 12-month follow-up of a controlled randomized multicenter trial.Techniques in coloproctology · 2020Trial
- Trial
- Functional outcomes from a randomized trial of early closure of temporary ileostomy after rectal excision for cancer.The British journal of surgery · 2019Trial
- Association Between Radiotherapy (±Chemotherapy) and the Severity of Low Anterior Resection Syndrome After Rectal Cancer Surgery: Does Radiotherapy Separate Risk?Medical sciences (Basel, Switzerland) · 2026Observational
- Impact of timing of ileostomy reversal and anastomotic leakage on bowel function and health-related quality of life following rectal cancer surgery: a cross-sectional study.Surgical endoscopy · 2026Article
- Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.Frontiers in oncology · 2026Article
- Low Anterior Resection Syndrome Evaluation and Management.Clinics in colon and rectal surgery · 2026Review
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Good local control acquired by chemoradiation for inoperable adenocarcinoma of the anal canal with pagetoid spread: a report of two cases.International cancer conference journal · 2026Article
- The first Dutch experience with a nurse-led outpatient clinic for the prevention and treatment of LARS after colorectal surgery: promising results of a standardized treatment protocol.Techniques in coloproctology · 2025Observational
- Quality of Life after Laparoscopic Sphincter-Preserving Total Mesorectal Excision for Low Rectal Cancer: A Single-Center Prospective Cohort Study in Vietnam.Asian Pacific journal of cancer prevention : APJCP · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDevelopments in surgical techniques and neoadjuvant treatment have enabled an increasing proportion of patients with rectal cancer to undergo sphincter-sparing resections. The avoidance of a permanent stoma can come at the cost of poor bowel function which can significantly impact patients' quality of life. The objective of this study was to identify the incidence and risk factors for the development of bowel dysfunction following rectal cancer surgery.
methodsPatients undergoing anterior resection for rectal cancer between January 2009 and January 2015 were identified from a rectal cancer database at a single centre. All patients who had bowel continuity restored and underwent curative resection were sent a validated low anterior resection syndrome (LARS) questionnaire. Pre-, inter- and postoperative factors were compared between patients with major LARS and those with minor or no LARS using conditional logistic regression.
resultsThere was an 80% response rate (n = 68). Thirty-eight patients (56%) had major LARS symptoms. Neoadjuvant radiotherapy, predominantly long-course chemoradiotherapy (LCCRT), was an independent risk factor for development of major LARS symptoms, while restoration of bowel continuity within 6 months was protective.
conclusionsThe use of neoadjuvant radiotherapy (LCCRT) and timing of stoma reversal are risk factors for the development of severe bowel dysfunction. The potential for long-term poor functional results after LCCRT should be discussed with patients and form a part of the decision-making in individual treatment plans. The timing of the ileostomy closure, where safe and feasible, should be performed within 6 months to improve outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.