ArticleNeurology2017
Predictors of incident epilepsy in older adults: The Cardiovascular Health Study.
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
- Vascular Risk Factors and Late-Onset Epilepsy.JAMA neurology · 2026Article
- Comparative trends in idiopathic epilepsy burden in China and worldwide based on Global Burden of Disease Study 2021.Epilepsy & behavior reports · 2026Article
- Association Between a Body Shape Index and Epilepsy Among US Adults: Potential Indirect Pathway Through Depressive Symptoms.Brain and behavior · 2026Article
- Sodium-glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real-world cohort study.Epilepsia · 2026Article
- Associations of Late-Onset Epilepsy With Myocardial Infarction and Nonstroke Vascular Death.Neurology · 2025Article
- Association of epilepsy with trajectory of depressive symptoms in late life: The Cardiovascular Health Study.Epilepsia · 2025Article
- The impact of white matter lesions on seizure recurrence after first epileptic seizures in the elderly: a prospective study.Neurological research and practice · 2025Article
- Serum Klotho levels and epilepsy among U.S. adults in the NHANES 2013-2016: a cross-sectional study.Scientific reports · 2025Article
- Management and outcomes among older adults with generalized epilepsy in routine clinical practice.Epilepsia open · 2025Article
- Racial/ethnic differences in the association of incident stroke with late onset epilepsy: The Northern Manhattan Study.Epilepsia · 2024Article
- Incident Epilepsy Among US Medicare Beneficiaries, 2019: Differences by Age, Sex, and Race/Ethnicity.Neurology · 2024Article
- Excess prevalence of preexisting chronic conditions in older adults with incident epilepsy.Epilepsia · 2024Article
- Association of Age-Related Neuropathologic Findings at Autopsy With a Claims-Based Epilepsy Diagnosis in Older Adults.Neurology · 2024Article
- Article
- Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies.Frontiers in neurology · 2024Review
- Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions.Frontiers in neurology · 2024Article
- Association of Plasma AβNeurology · 2023Article
- Long-term risk of seizure after posterior reversible encephalopathy syndrome.Annals of clinical and translational neurology · 2023Article
- Epilepsy, Vascular Risk Factors, and Cognitive Decline in Older Adults: The Cardiovascular Health Study.Neurology · 2022Article
- Association of Head Injury With Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Cohort.Neurology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the prevalence, incidence, and predictors of epilepsy among older adults in the Cardiovascular Health Study (CHS).
methodsWe analyzed data prospectively collected in CHS and merged with data from outpatient Medicare administrative claims. We identified cases with epilepsy using self-report, antiepileptic medication, hospitalization discharge ICD-9 codes, and outpatient Medicare ICD-9 codes. We used Cox proportional hazards regression to identify factors independently associated with incident epilepsy.
resultsAt baseline, 42% of the 5,888 participants were men and 84% were white. At enrollment, 3.7% (215 of 5,888) met the criteria for prevalent epilepsy. During 14 years of follow-up totaling 48,651 person-years, 120 participants met the criteria for incident epilepsy, yielding an incidence rate of 2.47 per 1,000 person-years. The period prevalence of epilepsy by the end of follow-up was 5.7% (335 of 5,888). Epilepsy incidence rates were significantly higher among blacks than nonblacks: 4.44 vs 2.17 per 1,000 person-years (
conclusionsEpilepsy in older adults in the United States was common. Blacks, the very old, and those with history of stroke have a higher risk of incident epilepsy. The association with race remains unexplained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.