SynthesisNeurology2017
Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis.
Open access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
9.0field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Leukoaraiosis Distribution and Cerebral Collaterals: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2022Pooled it
- The association between the severity and distribution of white matter lesions and hemorrhagic transformation after ischemic stroke: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Impact of leukoaraiosis severity on the association of outcomes of mechanical thrombectomy for acute ischemic stroke: a systematic review and a meta-analysis.Journal of neurology · 2021Pooled it
- Small Vessel Disease Burden and Outcomes of Mechanical Thrombectomy in Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Mechanical Thrombectomy for Acute Ischemic Stroke in Octogenarians: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke.JAMA network open · 2025Trial
- Changes of fatty acid metabolism in FA 26:0, FA 22:2 and FA 24:1 are associated with leukoaraiosis in the elderly.BMC geriatrics · 2026Article
- Impact of non-amyloid cerebral small vessel disease on the efficacy and safety of argatroban in acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- Analysis of Risk Factors for Leukoaraiosis: A Multicenter Retrospective Study.Brain and behavior · 2025Article
- White matter lesion effect modification of aspirin and unfractionated heparin during endovascular stroke treatment.Insights into imaging · 2025Article
- Cerebral Small Vessel Disease and Infarct Growth in Acute Ischemic Stroke Treated with Intravenous Thrombolysis.Translational stroke research · 2025Article
- Article
- Molecular and Neuroimaging Profile Associated with the Recurrence of Different Types of Strokes: Contribution from Real-World Data.Journal of clinical medicine · 2025Article
- Novel CT Image-Based Intracerebral Bleeding Risk Score for Patients With Acute Ischemic Stroke Undergoing Thrombolysis.Journal of the American Heart Association · 2025Article
- A comparative study of risk factors in predictive models for cognitive dysfunction in patients with leukoaraiosis based on machine learning algorithms.Frontiers in neuroscience · 2025Article
- Serum lipid profiling reveals characteristic lipid signatures associated with stroke in patients with leukoaraiosis.Scientific reports · 2024Article
- The impact of white matter hyperintensities on short-term outcomes of reperfusion therapy in patients with acute ischemic stroke.Journal of neurology · 2024Article
- Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of Leukoaraiosis in a South Chinese Han Population: A Case-Control Study.Biochemical genetics · 2024Article
- Deep learning-based white matter lesion volume on CT is associated with outcome after acute ischemic stroke.European radiology · 2024Article
- Cerebral small vessel disease and intracranial bleeding risk: Prognostic and practical significance.International journal of stroke : official journal of the International Stroke Society · 2023Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 5 countries.
Kannikar KongbunkiatFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Duncan WilsonFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Narongrit KasemsapFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Somsak TiamkaoFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Fatima JichiFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Vanessa PalumboFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Michael D HillFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Alastair M BuchanFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Simon JungFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Heinrich P MattleFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
Nils HenningerFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester.
David J WerringFrom the Stroke Research Centre (K.K., D.W., D.J.W.), Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK; Division of Neurology, Department of Medicine, Faculty of Medicine (K.K., N.K., S.T.), and North-Eastern Stroke Research Group (K.K., N.K., S.T.), Khon Kaen University, Thailand; UCL School of Life & Medical Sciences (F.J.), London, UK; Stroke Unit (V.P.), Department of Neurology, Careggi University Hospital, Florence, Italy; Hotchkiss Brain Institute (M.D.H.), Cumming School of Medicine, University of Calgary, Canada; Radcliffe Department of Medicine (A.M.B.), University of Oxford, John Radcliffe Hospital, UK; Department of Neurology (S.J., H.P.M.), Inselspital, University of Bern, Switzerland; and Departments of Neurology and Psychiatry (N.H.), University of Massachusetts Medical School, Worcester. d.werring@ucl.ac.uk.
Azienda Ospedaliero-Universitaria Careggi · ITJohn Radcliffe Hospital · GBUniversity College London · GBUniversity Hospital of Bern · CHUniversity of Bern · CHUniversity of Calgary · CAUniversity of Oxford · GB
Funding
Inhibiting axon degeneration in a mouse model of acute brain injury through deletion of Sarm1K08NS091499 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HENNINGER, NILS · 2016 to 2020
$919kNINDS NIH HHS K08 NS091499
Abstract
objectiveTo perform a systematic review and pooled meta-analysis of published studies to assess whether the presence of leukoaraiosis on neuroimaging before treatment with thrombolysis (IV or intra-arterial) is associated with an increased risk of symptomatic intracerebral hemorrhage (sICH) or poor functional outcome.
methodsWe included studies of patients with acute ischemic stroke, treated with IV or intra-arterial thrombolysis, which assessed functional outcome (3-month modified Rankin Scale [mRS]) or sICH in relation to leukoaraiosis on pretreatment neuroimaging (CT or MRI). We used random-effects models to calculate pooled relative risks (RR) of sICH and poor functional outcome (mRS ≥ 2) for any vs no leukoaraiosis (using any rating scale) and for no to mild vs moderate to severe leukoaraiosis (using the Van Swieten or Fazekas Schmidt scale).
resultsWe identified 15 studies (total n = 6,967). For sICH outcome, the RR was 1.65 (n = 5,551; 95% confidence interval [CI] 1.26-2.16,
conclusionsLeukoaraiosis presence and severity are consistently associated with an increased risk of sICH and poor functional outcome after IV or intra-arterial thrombolysis for acute ischemic stroke.
Indexed as
Brain IschemiaCerebral HemorrhageHumansLeukoaraiosisPrognosisRiskStrokeThrombolytic TherapyTreatment Outcome
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