ArticleThe Journal of experimental medicine2017
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.
Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease.Blood advances · 2019Trial
- T Cell Thoughts.Immunological reviews · 2026Review
- The relativity of regulatory T cell suppression modes.Frontiers in immunology · 2026Review
- Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception.Science immunology · 2025Article
- A Novel Approach of T Cell Receptor Classification Reveals Dynamic Interactions Amongst Diet, Microbiota, and Host T Cells.Immune network · 2025Review
- Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation.Nature immunology · 2025Article
- TCRosetta: An Integrated Analysis and Annotation Platform for T-cell Receptor Sequences.Genomics, proteomics & bioinformatics · 2024Article
- Article
- Boosting regulatory T cell function for the treatment of autoimmune diseases - That's only half the battle!Frontiers in immunology · 2022Review
- Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.Nature immunology · 2021Article
- A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance.Immunity · 2021Article
- TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function.Nucleic acids research · 2021Article
- Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation.Scientific reports · 2020Article
- Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism.Cell metabolism · 2020Review
- Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft-Haematologica · 2019Article
- Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications.Pharmacology & therapeutics · 2019Review
- Review
- Immune regulation and anti-cancer activity by lipid inflammatory mediators.International immunopharmacology · 2018Review
- CD49b defines functionally mature Treg cells that survey skin and vascular tissues.The Journal of experimental medicine · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The regulatory T cell (T reg cell) T cell receptor (TCR) repertoire is highly diverse and skewed toward recognition of self-antigens. TCR expression by T reg cells is continuously required for maintenance of immune tolerance and for a major part of their characteristic gene expression signature; however, it remains unknown to what degree diverse TCR-mediated interactions with cognate self-antigens are required for these processes. In this study, by experimentally switching the T reg cell TCR repertoire to a single T reg cell TCR, we demonstrate that T reg cell function and gene expression can be partially uncoupled from TCR diversity. An induced switch of the T reg cell TCR repertoire to a random repertoire also preserved, albeit to a limited degree, the ability to suppress lymphadenopathy and T helper cell type 2 activation. At the same time, these perturbations of the T reg cell TCR repertoire led to marked immune cell activation, tissue inflammation, and an ultimately severe autoimmunity, indicating the importance of diversity and specificity for optimal T reg cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.