Evidence map›Paper›PMID 28130354›Full record

ArticleDisease models & mechanisms2017

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat.

Philip M Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J Aitman

Open access · goldAbstract readComparative Study
In one paragraph

Article in Disease models & mechanisms, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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  12. Rat Models of Metabolic Syndrome.Methods in molecular biology (Clifton, N.J.) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Philip M CoanCentre for Genomic and Experimental Medicine & Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH4 2XU, UK p.m.coan.02@cantab.net.ORCID 0000-0001-6158-380X
Oliver HummelCardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC), 13125 Berlin, Germany.
Ana Garcia DiazDepartment of Medicine, Imperial College London, London SW7 2AZ, UK.
Marjorie BarrierCentre for Genomic and Experimental Medicine & Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH4 2XU, UK.
Neza AlfazemaCentre for Genomic and Experimental Medicine & Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH4 2XU, UK.
Penny J NorsworthyMRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK.
Michal PravenecDepartment of Model Diseases, Institute of Physiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Enrico PetrettoMRC Clinical Sciences Centre, Imperial College London, London W12 0NN, UK.
Norbert HübnerCardiovascular and Metabolic Sciences, Max-Delbrück-Center for Molecular Medicine (MDC), 13125 Berlin, Germany.
Timothy J AitmanCentre for Genomic and Experimental Medicine & Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-7875-4502
The Queen's Medical Research Institute · GBImperial College London · GBMax Delbrück Center · DECzech Academy of Sciences · CZDuke-NUS Medical School · SG

Funding

Medical Research Council MC_U120061454Medical Research Council MC_U120097112
6 · The paper itself

Abstract

We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses between spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, and subsequently identified

Indexed as

GenomicsAnimalsBlood PressureBody WeightCalorimetryCardiomegalyChromosomes, MammalianEnergy MetabolismFeeding BehaviorGene Expression RegulationGenome-Wide Association StudyHeart VentriclesHomeostasisHumansHypertensionInsulinInsulinTriglyceridesCongenicGenomicHypertensionInsulin resistanceRat

Identifiers

PMID28130354
PMCPMC5374317
OpenAlexW2581177295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.