Evidence map›Paper›PMID 28130333›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

Can endothelial hemoglobin-α regulate nitric oxide vasodilatory signaling?

Jaimit Parikh, Adam Kapela, Nikolaos M Tsoukias

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jaimit ParikhDepartment of Biomedical Engineering, Florida International University, Miami, Florida; and.
Adam KapelaDepartment of Biomedical Engineering, Florida International University, Miami, Florida; and.
Nikolaos M TsoukiasDepartment of Biomedical Engineering, Florida International University, Miami, Florida; and tsoukias@fiu.edu.
Florida International University · USNational Technical University of Athens · GR

Funding

Theorectal and Experimental Investigations of Microcirculatory SignalingSC1HL095101 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2008 to 2012
$1.4M
Integrative modeling to link vascular phenotype to gene expressionR15HL121778 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI TSOUKIAS, NIKOLAOS MICHAEL · 2014 to 2014
$424k
NHLBI NIH HHS R15 HL121778NHLBI NIH HHS SC1 HL095101
6 · The paper itself

Abstract

We used mathematical modeling to investigate nitric oxide (NO)-dependent vasodilatory signaling in the arteriolar wall. Detailed continuum cellular models of calcium (Ca

Indexed as

AlgorithmsComputer SimulationEndothelium, VascularErythrocytesFeedback, PhysiologicalHemoglobin AHumansInositol 1,4,5-Trisphosphate ReceptorsModels, TheoreticalNitric OxideNitric Oxide Synthase Type IIIPotassium Channels, Calcium-ActivatedSignal TransductionVasodilationHemoglobin AInositol 1,4,5-Trisphosphate ReceptorsNitric OxideNitric Oxide Synthase Type IIINOS3 protein, humanPotassium Channels, Calcium-Activatedcalcium dynamicscompartmentalizationmyoendothelial signalingsmooth muscle cellvasorelaxation

Identifiers

PMID28130333
PMCPMC5407155
OpenAlexW2580112151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.