Evidence map›Paper›PMID 28130314›Full record

ReviewCold Spring Harbor perspectives in medicine2018

Disease Mechanisms of

Tania F Gendron, Leonard Petrucelli

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Microprotein Regulates G-quadruplex Driven RNA Aggregation.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. DNA methylation as a contributor to dysregulation ofbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Biomolecular Condensates Can Enhance Homotypic RNA Clustering.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. iScience · 2023
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tania F GendronDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida 32224.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida 32224.

Funding

Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6M
TDP-43, RNA Metabolism, and ALS/FTD PathologyR01NS063964 · NINDS · UNIVERSITY OF COLORADO · PI LINK, CHRISTOPHER D. · 2009 to 2019
$3.5M
Misregulation of the TDP-43 RNA target, Sortilin, in neurodegenerationR01NS077402 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2011 to 2015
$1.7M
Silencing C9or72 with rAAV Mediated RNAiR01NS088689 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BROWN, ROBERT H., MUELLER, CHRISTIAN · 2014 to 2017
$1.6M
RNA foci in C9FTD/ALSR21NS084528 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2013 to 2014
$430k
c9RAN proteins as a biomarker for C9ORF72-associated ALS and FTDR21NS089979 · NINDS · MAYO CLINIC JACKSONVILLE · PI BOYLAN, KEVIN, GENDRON, TANIA FRANCE · 2014 to 2015
$422k
NINDS NIH HHS P01 NS084974NINDS NIH HHS R01 NS063964NINDS NIH HHS R01 NS077402NINDS NIH HHS R01 NS088689NINDS NIH HHS R21 NS084528NINDS NIH HHS R21 NS089979
6 · The paper itself

Abstract

G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinDNA Repeat ExpansionFrontotemporal DementiaHumansRNA, AntisenseRNA IsoformsC9orf72 ProteinC9orf72 protein, humanRNA, AntisenseRNA Isoforms

Identifiers

PMID28130314
PMCPMC5880161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.