Evidence map›Paper›PMID 28130264›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Vagal innervation is required for pulmonary function phenotype in

John S House, Cody E Nichols, Huiling Li, Christina Brandenberger, Rohan S Virgincar, Laura M DeGraff, Bastiaan Driehuys, Darryl C Zeldin, Stephanie J London

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Lrp1 Regulation of Pulmonary Function. Follow-Up of Human GWAS in Mice.American journal of respiratory cell and molecular biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

John S HouseImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID http://orcid.org/0000-0002-8447-7871
Cody E NicholsImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Huiling LiImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Christina BrandenbergerInstitute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
Rohan S VirgincarCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Laura M DeGraffImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Bastiaan DriehuysCenter for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina.
Darryl C ZeldinImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Stephanie J LondonImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; london2@niehs.nih.gov.ORCID http://orcid.org/0000-0003-4911-5290
National Institute of Environmental Health Sciences · USDuke University · USMedizinische Hochschule Hannover · DE

Funding

Molecular Genetics Support to Identify Gene/Environment Interactions in DiseaseZICES102546 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GERRISH, KEVIN · 2009 to 2025
$30.5M
NIEHS Knock Out Mouse Core (KOMC) Annual ReportZICES102425 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RAY, MANAS · 2010 to 2025
$20.1M
Alterations In Pulmonary Immune Function And Host Resistance In COX Null MiceZIAES025043 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$11.7M
INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Genetic Analyses For Epidemiologic Studies Of Respiratory DiseaseZIAES025045 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$7.3M
Genetic /Environment Factors In Nonmalignant Resp DisZ01ES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1999 to 2008
$340k
Intramural NIH HHS Z01 ES043012NIBIB NIH HHS P41 EB015897
6 · The paper itself

Abstract

Human genome-wide association studies have identified over 50 loci associated with pulmonary function and related phenotypes, yet follow-up studies to determine causal genes or variants are rare. Single nucleotide polymorphisms in serotonin receptor 4 (

Indexed as

AnimalsGenotypeIn Vitro TechniquesLungMice, Inbred C57BLMuscle ContractionPhenotypePulmonary VentilationReceptors, Serotonin, 5-HT4RespirationRespiratory Function TestsRespiratory HypersensitivityTracheaVagotomyVagus NerveReceptors, Serotonin, 5-HT4airway hyperresponsivenesscontrol of breathingmouse modelspulmonary functionvagal innervation

Identifiers

PMID28130264
PMCPMC5407097
OpenAlexW2580881032

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.