ArticleBiochimica et biophysica acta. General subjects2017
What killed Karl Patterson Schmidt? Combined venom gland transcriptomic, venomic and antivenomic analysis of the South African green tree snake (the boomslang), Dispholidus typus.
Article in Biochimica et biophysica acta. General subjects, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 61 citations in OpenAlex.
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- Divergent Specialization of Simple Venom Gene Profiles among Rear-Fanged Snake Genera (Toxins · 2022Article
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- Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins.BMC biology · 2022Article
- A case report of detecting subclinical coagulopathy in a patient with boomslang (Dipholidus typus) bite.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2021Article
- Convergent evolution of pain-inducing defensive venom components in spitting cobras.Science (New York, N.Y.) · 2021Article
- Investigating Toxin Diversity and Abundance in Snake Venom Proteomes.Frontiers in pharmacology · 2021Review
- Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates.Toxins · 2020Article
- High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.PLoS neglected tropical diseases · 2020Article
- Trait differentiation and modular toxin expression in palm-pitvipers.BMC genomics · 2020Article
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- Beyond the 'big four': Venom profiling of the medically important yet neglected Indian snakes reveals disturbing antivenom deficiencies.PLoS neglected tropical diseases · 2019Article
- Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey.Journal of proteomics · 2019Article
- A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.Frontiers in pharmacology · 2019Article
- Three-Finger Toxin Diversification in the Venoms of Cat-Eye Snakes (Colubridae: Boiga).Journal of molecular evolution · 2018Article
- Antibody Cross-Reactivity in Antivenom Research.Toxins · 2018Review
- Adaptive evolution of distinct prey-specific toxin genes in rear-fanged snake venom.Proceedings. Biological sciences · 2018Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
backgroundNon-front-fanged colubroid snakes comprise about two-thirds of extant ophidian species. The medical significance of the majority of these snakes is unknown, but at least five species have caused life-threatening or fatal human envenomings. However, the venoms of only a small number of species have been explored.
methodsA combined venomic and venom gland transcriptomic approach was employed to characterise of venom of Dispholidus typus (boomslang), the snake that caused the tragic death of Professor Karl Patterson Schmidt. The ability of CroFab™ antivenom to immunocapture boomslang venom proteins was investigated using antivenomics.
resultsTranscriptomic-assisted proteomic analysis identified venom proteins belonging to seven protein families: three-finger toxin (3FTx); phospholipase A
conclusionsThe present work is the first to address the overall proteomic profile of D. typus venom. This study allowed us to correlate the toxin composition with the toxic activities of the venom. The antivenomic analysis suggested that the antivenom available at the time of the unfortunate accident could have exhibited at least some immunoreactivity against the boomslang SVMPs responsible for the disseminated intravascular coagulation syndrome that caused K.P. Schmidt's fatal outcome. GENERAL SIGNIFICANCE: This study may stimulate further research on other non-front-fanged colubroid snake venoms capable of causing life-threatening envenomings to humans, which in turn should contribute to prevent fatal human accidents, such as that unfortunately suffered by K.P. Schmidt.
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