Evidence map›Paper›PMID 28130147›Full record

ArticleTheoretical population biology2017

Theory of partitioning of disease prevalence and mortality in observational data.

I Akushevich, A P Yashkin, J Kravchenko, F Fang, K Arbeev, F Sloan, A I Yashin

Abstract read
In one paragraph

Article in Theoretical population biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Spatiotemporal analysis of diarrhea-related hospitalizations of children in Brazil's Midwest region from 2011 to 2020.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

I AkushevichBiodemography of Aging Research Unit, Center for Population Health and Aging, Duke University, Durham, NC, United States. Electronic address: igor.akushevich@duke.edu.
A P YashkinBiodemography of Aging Research Unit, Center for Population Health and Aging, Duke University, Durham, NC, United States.
J KravchenkoDepartment of Surgery, Duke University School of Medicine, Durham, NC, United States.
F FangBiodemography of Aging Research Unit, Center for Population Health and Aging, Duke University, Durham, NC, United States.
K ArbeevBiodemography of Aging Research Unit, Center for Population Health and Aging, Duke University, Durham, NC, United States.
F SloanDepartment of Economics, Duke University, Durham, NC, United States.
A I YashinBiodemography of Aging Research Unit, Center for Population Health and Aging, Duke University, Durham, NC, United States.

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
Relationships among Genetic Regulators of Aging Health and LifespanP01AG043352 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$8.7M
Genetics of changes in population pyramids: Implications for health forecasting with a focus on Alzheimer's Disease and related dementiasRF1AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2019 to 2019
$3.1M
YASHIN Admin Supp: Time Trends in Alzheimer's Disease: Addressing the Changing Role of Risk Factors and Instrument ValidityR01AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$3.1M
VISUAL IMPAIRMENT, TREATMENT, AND EFFECTS ON THE ELDERLYR01AG017473 · NIA · DUKE UNIVERSITY · PI SLOAN, FRANK A · 2001 to 2012
$1.7M
NIA NIH HHS P01 AG043352NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG017473NIA NIH HHS R01 AG046860NIA NIH HHS RF1 AG046860
6 · The paper itself

Abstract

In this study, we present a new theory of partitioning of disease prevalence and incidence-based mortality and demonstrate how this theory practically works for analyses of Medicare data. In the theory, the prevalence of a disease and incidence-based mortality are modeled in terms of disease incidence and survival after diagnosis supplemented by information on disease prevalence at the initial age and year available in a dataset. Partitioning of the trends of prevalence and mortality is calculated with minimal assumptions. The resulting expressions for the components of the trends are given by continuous functions of data. The estimator is consistent and stable. The developed methodology is applied for data on type 2 diabetes using individual records from a nationally representative 5% sample of Medicare beneficiaries age 65+. Numerical estimates show excellent concordance between empirical estimates and theoretical predictions. Evaluated partitioning model showed that both prevalence and mortality increase with time. The primary driving factors of the observed prevalence increase are improved survival and increased prevalence at age 65. The increase in diabetes-related mortality is driven by increased prevalence and unobserved trends in time-periods and age-groups outside of the range of the data used in the study. Finally, the properties of the new estimator, possible statistical and systematical uncertainties, and future practical applications of this methodology in epidemiology, demography, public health and health forecasting are discussed.

Indexed as

AgedAged, 80 and overDiabetes Mellitus, Type 2ForecastingHumansIncidenceMedicarePrevalenceSurvival AnalysisUnited StatesDiabetesIncidenceMortalityPartitioningPrevalenceTime trend

Identifiers

PMID28130147
PMCPMC5459580

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.