Evidence map›Paper›PMID 28130073›Full record

ArticleThe Journal of investigative dermatology2017

Hedgehog Signaling Inhibitors Fail to Reduce Merkel Cell Carcinoma Viability.

Thomas M Carroll, Jonathan S Williams, Kenneth Daily, Tova Rogers, Tara Gelb, Amy Coxon, Steven Q Wang, Aimee M Crago, Klaus J Busam, Isaac Brownell

Abstract readCase ReportsLetter
In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Update on Merkel Cell Carcinoma.Head and neck pathology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas M CarrollDermatology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Jonathan S WilliamsDermatology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Kenneth DailyDermatology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Tova RogersDermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Tara GelbDermatology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Amy CoxonDermatology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Steven Q WangDermatology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Aimee M CragoGastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Klaus J BusamDepartment of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Isaac BrownellDermatology Branch, National Cancer Institute, Bethesda, Maryland, USA. Electronic address: isaac.brownell@nih.gov.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Molecular pathogenesis of Merkel cell carcinomaZIABC011394 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BROWNELL, ISAAC · 2011 to 2021
$6.8M
Development and regulation of stem cell lineages in skinZIABC011393 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BROWNELL, ISAAC · 2011 to 2021
$6.7M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, NeoplasticAgedAnilidesBiopsyCarcinoma, Merkel CellCell Line, TumorDrug Screening Assays, AntitumorFatal OutcomeHedgehog ProteinsHumansMaleOligonucleotide Array Sequence AnalysisPyridinesSignal TransductionSkin NeoplasmsTomography, X-Ray ComputedAnilidesHedgehog ProteinsHhAntag691Pyridines

Identifiers

PMID28130073
PMCPMC5629915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.