ArticleThe Canadian journal of cardiology2017
Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population.
Article in The Canadian journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pooled it
- Genetic variants and polygenic risk scores associated with paroxysmal atrial fibrillation in the Japanese population.PloS one · 2026Article
- Age-Dependent Contributions of Rare and Common Genetic Variation in Atrial Fibrillation.Circulation. Genomic and precision medicine · 2025Article
- The cardiac blood transcriptome predicts de novo onset of atrial fibrillation in heart failure.Journal of molecular and cellular cardiology plus · 2024Article
- Influence of ZFHX3 Polymorphisms on the Risk of Ischemic Stroke in Chinese Han Population.Cardiovascular toxicology · 2023Article
- Influence of ZFHX3 Polymorphisms on the Risk of Ischemic Stroke in Chinese Han Population.Cardiovascular toxicology · 2023Article
- Genetic risk factors for postoperative atrial fibrillation-a nationwide genome-wide association study (GWAS).Frontiers in cardiovascular medicine · 2023Article
- Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers.PloS one · 2023Article
- JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias.Journal of arrhythmia · 2022Article
- Transcriptional factors in calcium mishandling and atrial fibrillation development.Pflugers Archiv : European journal of physiology · 2021Review
- Genetic variants associated with atrial fibrillationand long-term recurrence after catheter ablation for atrialfibrillation in Turkish patients.Anatolian journal of cardiology · 2021Article
- A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population.Metabolic syndrome and related disorders · 2018Article
- PITX2 deficiency and associated human disease: insights from the zebrafish model.Human molecular genetics · 2018Article
- Genetics of atrial fibrillation: an update.Current opinion in cardiology · 2018Review
- Genetic Risk Scores for Atrial Fibrillation: Do They Improve Risk Estimation?The Canadian journal of cardiology · 2017Article
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9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) affects millions of individuals worldwide. The genome-wide association studies have identified robust genetic associations with AF.
methodsWe genotyped 5461 participants of Japanese ancestry for 11 AF-related loci and determined the effects of carrying different numbers of risk alleles on disease development and age at disease onset. The weighted genetic risk score (GRS) was calculated, and its ability to predict AF was determined.
resultsSix single-nucleotide polymorphisms-rs593479 (1q24 in PRRX1), rs1906617 (4q25 near PITX2), rs11773845 (7q31 in CAV1), rs6584555 (10q25 in NEURL), rs6490029 (12q24 in CUX2), and rs12932445 (16q22 in ZFHX3) (P < 1.9 × 10
conclusionsSix loci were validated as associated with AF in a Japanese population. This study suggests that a combination of common genetic markers modestly facilitates discrimination of AF. This is the first report, to our knowledge, to demonstrate that the age of onset of AF is affected by common risk alleles.
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