Evidence map›Paper›PMID 28129789›Full record

Trial reportRadiation oncology (London, England)2017

Short report: interim safety results for a phase II trial measuring the integration of stereotactic ablative radiotherapy (SABR) plus surgery for early stage non-small cell lung cancer (MISSILE-NSCLC).

David A Palma, Timothy K Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V Louie, Eric Frechette, George B Rodrigues and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02136355 (A Phase II Trial Measuring the Integration of Stereotactic Radiotherapy Plus Surgery in Early Non-Small Cell Lung Cancer), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02136355 nacompletednot on this map

A Phase II Trial Measuring the Integration of Stereotactic Radiotherapy Plus Surgery in Early Non-Small Cell Lung Cancer

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2014 to 2022Enrolled40ConditionsNon Small Cell Lung CancerArmsStereotactic Body Radiation Therapy plus Surgery
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Template-assistedJournal of contemporary brachytherapy · 2019
    Article
  5. Review
  6. Review
  7. Article
  8. Lobectomy: no port at all?Annals of translational medicine · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

David A PalmaDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada. David.Palma@lhsc.on.ca.
Timothy K NguyenDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Keith KwanDepartment of Pathology, Western University, London, Canada.
Stewart GaedeDepartment of Oncology, Western University, London, Canada.
Mark LandisDepartment of Radiology, Western University, London, Canada.
Richard MalthanerDepartment of Surgery, Division of Thoracic Surgery, Western University, London, Canada.
Dalilah FortinDepartment of Surgery, Division of Thoracic Surgery, Western University, London, Canada.
Alexander V LouieDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Eric FrechetteDepartment of Surgery, Division of Thoracic Surgery, Western University, London, Canada.
George B RodriguesDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Brian YaremkoDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Edward YuDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
A Rashid DarDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Ting-Yim LeeDepartment of Medical Biophysics, Western University, London, Canada.
Al GrattonDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Andrew WarnerDepartment of Radiation Oncology, London Health Sciences Centre, London, Canada.
Aaron WardDepartment of Oncology, Western University, London, Canada.
Richard InculetDepartment of Surgery, Division of Thoracic Surgery, Western University, London, Canada.
Western University · CALondon Health Sciences Centre · CALawson Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We report a mandated interim safety analysis for the first 10 patients who completed protocol treatment. Operable patients with biopsy-proven T1-2 N0 NSCLC were eligible. SABR was delivered using a risk-adapted fractionation (54Gy/3 fractions, 55/5 or 60/8). Surgical resection was planned 10 weeks later at a high-volume center (>200 lung cancer resections annually). Patients were imaged with dynamic positron emission tomography-computed tomography scans using

trial registrationNCT02136355 . Registered 8 May 2014.

Indexed as

AgedCarcinoma, Non-Small-Cell LungCombined Modality TherapyFemaleHumansLung NeoplasmsMaleMiddle AgedNeoadjuvant TherapyPneumonectomyRadiosurgeryTreatment OutcomeLung cancerNon-small cellStereotactic ablative radiotherapyStereotactic body radiotherapySurgery

Identifiers

PMID28129789
PMCPMC5270342
OpenAlexW2581046071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.