ArticleFEBS letters2017
Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy.
Article in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
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- Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy.Skeletal muscle · 2023Article
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- Effects of maternal dietary energy restriction on breast muscle fibre development in the offspring of broiler breeders.Animal bioscience · 2021Article
- Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions.Skeletal muscle · 2021Review
- Hepatic Steatosis Contributes to the Development of Muscle AtrophyFrontiers in endocrinology · 2021Article
- Scleraxis is required for the growth of adult tendons in response to mechanical loading.JCI insight · 2020Article
- Marker Expression of Interstitial Cells in Human Skeletal Muscle: An Immunohistochemical Study.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- The impact of skeletal muscle contraction on CD146American journal of physiology. Cell physiology · 2019Article
- Insulin-like growth factor 1 signaling in tenocytes is required for adult tendon growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells.Stem cell reports · 2019Article
- Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling.American journal of physiology. Cell physiology · 2018Article
- Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation.Physiology (Bethesda, Md.) · 2018Review
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5 authors at 1 institution in 1 country.
Funding
Abstract
The platelet-derived growth factor receptors alpha and beta (PDGFRα and PDGFRβ) mark fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. While the role that these cells play in muscle growth and development has been evaluated, it was not known whether the PDGF receptors activate signaling pathways that control transcriptional and functional changes during skeletal muscle hypertrophy. To evaluate this, we inhibited PDGFR signaling in mice subjected to a synergist ablation muscle growth procedure, and performed analyses 3 and 10 days after induction of hypertrophy. The results from this study indicate that PDGF signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.
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