Evidence map›Paper›PMID 28129590›Full record

Trial reportGait & posture2017

Functional implications of muscle co-contraction during gait in advanced age.

Justine Lo, On-Yee Lo, Erin A Olson, Daniel Habtemariam, Ikechukwu Iloputaife, Margaret M Gagnon, Brad Manor, Lewis A Lipsitz

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Gait & posture, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026
    Review
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  16. Muscular and Prefrontal Cortex Activity during Dual-Task Performing in Young Adults.European journal of investigation in health, psychology and education · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Justine LoInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA. Electronic address: JustineLo@hsl.harvard.edu.
On-Yee LoInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA. Electronic address: AmyLo@hsl.harvard.edu.
Erin A OlsonInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA. Electronic address: erinalexisolson@gmail.com.
Daniel HabtemariamInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA. Electronic address: DanielHabtemariam@hsl.harvard.edu.
Ikechukwu IloputaifeInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA. Electronic address: Iloputaife@hsl.harvard.edu.
Margaret M GagnonInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA. Electronic address: Gagnon@hsl.harvard.edu.
Brad ManorInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA; Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA. Electronic address: BradManor@hsl.harvard.edu.
Lewis A LipsitzInstitute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA; Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA. Electronic address: Lipsitz@hsl.harvard.edu.
Hebrew SeniorLife · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Translational Researchin Aging Trainnig ProgramT32AG023480 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2004 to 2024
$7.6M
Health Outcomes of Tai Chi in Subsidized Senior HousingR01AG025037 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS, WAYNE, PETER MICHAEL · 2015 to 2019
$3.5M
Cerebrovascular Mechanisms of Slow Gait and FallsR01AG041785 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2013 to 2017
$2.4M
Modulating brain activity to preserve gait in older adults.K01AG044543 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MANOR, BRADLEY D. · 2014 to 2016
$373k
NCATS NIH HHS UL1 TR001102NIA NIH HHS K01 AG044543NIA NIH HHS R01 AG025037NIA NIH HHS R01 AG041785NIA NIH HHS T32 AG023480
6 · The paper itself

Abstract

Older adults often exhibit high levels of lower extremity muscle co-contraction, which may be the cause or effect of age-related impairments in gait and associated falls. Normal gait requires intact executive function and thus can be slowed by challenging executive resources available to the neuromuscular system through the performance of a dual task. We therefore investigated associations between lower limb co-contraction and gait characteristics under normal and dual task conditions in healthy older adults (85.4±5.9years). We hypothesized that greater co-contraction is associated with slower gait speed during dual task conditions that stress executive and attentional abilities. Co-contraction was quantified during different phases of the gait cycle using surface electromyography (EMG) signals obtained from the anterior tibialis and lateral gastrocnemius while walking at preferred speed during normal and dual task conditions. Variables included the time difference to complete the Trail Making Test A and B (ΔTMT) and gait measures during normal or dual task walking. Higher co-contraction levels during the swing phase of both normal and dual task walking were associated with longer ΔTMT (normal: R

Indexed as

AgingGaitWalkingAgedAged, 80 and overElectromyographyFemaleHumansLower ExtremityMaleMuscle ContractionAgingDual taskGaitMuscle co-contraction

Identifiers

PMID28129590
PMCPMC5346031
OpenAlexW2579359310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.