Evidence map›Paper›PMID 28129536›Full record

ReviewCell2017

A Red Carpet for Iron Metabolism.

Martina U Muckenthaler, Stefano Rivella, Matthias W Hentze, Bruno Galy

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 725 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
725citing papers in PubMed, 5 pooled it
63.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

725 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,290 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. The neogenin-hemojuvelin axis in murine liver is crucial for hepcidin expression.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Ferroptosis in kidney disease.Nature reviews. Nephrology · 2026
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Iron Overload: Pathophysiology, Diagnosis and Monitoring.International journal of laboratory hematology · 2026
    Review
  19. Article
  20. Article

665 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Martina U MuckenthalerMolecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany.
Stefano RivellaChildren's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA.
Matthias W HentzeMolecular Medicine Partnership Unit, European Molecular Biology Laboratory and University of Heidelberg, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany; European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address: hentze@embl.de.
Bruno GalyDivision of Virus-Associated Carcinogenesis (F170), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Heidelberg University · DEChildren's Hospital of Philadelphia · USGerman Cancer Research Center · DE

Funding

Regulatory Role of Transferrin in Erythropoiesis and Iron MetabolismR01DK095112 · NIDDK · SAINT LOUIS UNIVERSITY · PI Robert E Fleming, Yelena Ginzburg · 2012 to 2026
$5.4M
Hepcidin therapy for iron overload and hematologic disordersR01DK090554 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2021
$5.2M
The influence of genotype on the outcome of gene transfer in beta-thalassemiaR01HL102449 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RIVELLA, STEFANO · 2010 to 2014
$2.1M
NHLBI NIH HHS R01 HL102449NIDDK NIH HHS R01 DK090554NIDDK NIH HHS R01 DK095112
6 · The paper itself

Abstract

200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 10

Indexed as

AnemiaAnimalsBiological TransportErythroid CellsErythropoiesisHepcidinsHumansInflammationIronIron, DietaryHepcidinsIronIron, Dietary

Identifiers

PMID28129536
PMCPMC5706455
OpenAlexW2580415908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.