ArticlePloS one2017
Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Polyphenol-Rich Mangosteen Pericarp Extract Attenuates Metabolic and Reproductive Dysfunction in High-fat Diet and Streptozotocin-induced Obese-Diabetic Male Rats: A Preliminary Study.Applied biochemistry and biotechnology · 2026Article
- Modulation of PDX1 gene expression and glycemic control by Citrullus lanatus in experimental type 2 diabetes.Scientific reports · 2026Article
- Article
- Efficacy of Fetal Wharton's Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome.Biomolecules · 2025Article
- Interleukin 1β receptor blocker (Anakinra) and regenerative stem cell therapy: two novel approaches effectively ameliorating diabetic cardiomyopathy.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Longitudinal Analysis of Bone Metabolic Markers and Bone Mechanical Properties in STZ-Induced Diabetic Rats.Journal of clinical medicine · 2024Article
- Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Current obesity reports · 2024Review
- Oleic Acid and Succinic Acid: A Potent Nutritional Supplement in Improving Hepatic Glycaemic Control in Type 2 Diabetic Sprague-Dawley Rats.Advances in pharmacological and pharmaceutical sciences · 2024Article
- Dose-dependent anti-hyperglycemic & anti-dyslipidemic potential of aqueous leaves extract ofSaudi journal of biological sciences · 2023Article
- Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects.Molecular biology reports · 2023Article
- Antidiabetic, Antioxidant and Anti-Inflammatory Activities of Residual Aqueous Fraction ofTropical life sciences research · 2023Article
- The Antihyperglycemic Effect of Crude Liang (Journal of nutrition and metabolism · 2023Article
- Development and optimization of amphiphilic self-assembly into nanostructured liquid crystals for transdermal delivery of an antidiabetic SGLT2 inhibitor.Drug delivery · 2022Article
- The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced diabetic rats.Veterinary world · 2022Article
- Characterization of a Coproduct from the Sea CucumberMarine drugs · 2020Article
- In Vivo Studies of Inoculated Plants and In Vitro Studies Utilizing Methanolic Extracts of EndophyticInternational journal of molecular sciences · 2020Article
- The Effects and Mechanism of Quercetin Dietary Supplementation in Streptozotocin-Induced Hyperglycemic Arbor Acre Broilers.Oxidative medicine and cellular longevity · 2020Article
- The protective effect of neonatal oral administration of oleanolic acid against the subsequent development of fructose-induced metabolic dysfunction in male and female rats.Nutrition & metabolism · 2018Article
- Insulin-loaded PLGA microspheres for glucose-responsive release.Drug delivery · 2017Article
- Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes.Medicines (Basel, Switzerland) · 2017Article
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Abstract
backgroundPathophysiological investigation of disease in a suitable animal model is a classical approach towards development of a credible therapeutic strategy. This study examined appropriate insulin level in selecting animal model for type 2 diabetes (T2D) studies.
methodAlbino Wistar rats (150-200g) were divided into two groups fed with commercially available normal-diet-feed (NDF) and water or fortified diet feed (FDF) (10g NDF per gram of margarine) with 20% fructose solution as drinking water. After 6 weeks of dietary regimen both groups were divided into 5 sub-groups and injected intraperitoneally with a graded dose of streptozotocin (STZ) (0, 25, 35, 45 & 55mg/kg bw.).
resultThe result showed that the FDF-fed rats increased significantly in body weight, basal serum insulin, total cholesterol, triglycerides and blood glucose levels as compared to NDF-fed rats. Ten days post STZ induction, the groups treated with STZ (45 & 55 mg/kg) developed frank hyperglycaemia with < 46.8% serum insulin, a severe deficiency typical of diabetes type 1. The NDF25 and NDF35 groups with 75.7% and 64.4% serum insulin respectively presented relative normoglycemia, whereas the FDF35 (85.8% serum insulin) were notably hyperglycaemia (>300 mg/dL) throughout the 6weeks post diabetes confirmation. These FDF35 rats were sensitive to glibenclamide, metformin and pioglitazone in lowering hyperglycaemia, hypertriglyceridemia and hypercholesterolemia.
conclusionThe hyperglycaemia stability of the FDF35 rats (85.5% insulin) together with their sensitivity to 3 different hypoglycaemic drugs strongly suggests their suitability as a non-genetic model of T2D. Hence the study shows that circulating serum insulin ≥ 85.8% with overt hyperglycaemia may be utilized as the benchmark in selecting rat models for T2D studies.
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