Evidence map›Paper›PMID 28129256›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Loss to Follow-up Trends in HIV-Positive Patients Receiving Antiretroviral Treatment in Asia From 2003 to 2013.

Nicole L De La Mata, Penh S Ly, Kinh V Nguyen, Tuti P Merati, Thuy T Pham, Man P Lee, Jun Y Choi, Jeremy Ross, Matthew G Law, Oon T Ng

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 7 countries.

Nicole L De La Mata*Biostatistics and Databases Program, The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; †National Center for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ‡National Hospital for Tropical Diseases, Hanoi, Vietnam; §Department of Internal Medicine, Tropical and Infectious Diseases, Udayana University and Sanglah Hospital, Bali, Indonesia; ‖Bach Mai Hospital, Hanoi, Vietnam; ¶Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China; **Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Severance Hospital, Seoul, South Korea; ††TREAT Asia, amfAR-The Foundation for AIDS Research, Bangkok, Thailand; and ‡‡Department of Infectious Diseases, Tan Tock Seng Hospital, Novena, Singapore.
Penh S Ly
Kinh V Nguyen
Tuti P Merati
Thuy T Pham
Man P Lee
Jun Y Choi
Jeremy Ross
Matthew G Law
Oon T Ng
UNSW Sydney · AUBạch Mai Hospital · VNHospital for Tropical Diseases · VNNational Center for HIV/AIDS, Dermatology and STD · KHQueen Elizabeth Hospital · CNSeverance Hospital · KRTan Tock Seng Hospital · SGUdayana University · ID

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
NIAID NIH HHS U01 AI069907
6 · The paper itself

Abstract

introductionOver time, there has been a substantial improvement in antiretroviral treatment (ART) programs, including expansion of services and increased patient engagement. We describe time trends in, and factors associated with, loss to follow-up (LTFU) in HIV-positive patients receiving ART in Asia.

methodsAnalysis included HIV-positive adults initiating ART in 2003-2013 at 7 ART programs in Asia. Patients LTFU had not attended the clinic for ≥180 days, had not died, or transferred to another clinic. Patients were censored at recent clinic visit, follow-up to January 2014. We used cumulative incidence to compare LTFU and mortality between years of ART initiation. Factors associated with LTFU were evaluated using a competing risks regression model, adjusted for clinical site.

resultsA total of 8305 patients were included. There were 743 patients LTFU and 352 deaths over 26,217 person-years (pys), a crude LTFU, and mortality rate of 2.83 (2.64-3.05) per 100 pys and 1.34 (1.21-1.49) per 100 pys, respectively. At 24 months, the cumulative LTFU incidence increased from 4.3% (2.9%-6.1%) in 2003-05 to 8.1% (7.1%-9.2%) in 2006-09 and then decreased to 6.7% (5.9%-7.5%) in 2010-13. Concurrently, the cumulative mortality incidence decreased from 6.2% (4.5%-8.2%) in 2003-05 to 3.3% (2.8%-3.9%) in 2010-13. The risk of LTFU reduced in 2010-13 compared with 2006-09 (adjusted subhazard ratio = 0.73, 0.69-0.99).

conclusionsLTFU rates in HIV-positive patients receiving ART in our clinical sites have varied by the year of ART initiation, with rates declining in recent years whereas mortality rates have remained stable. Further increases in site-level resources are likely to contribute to additional reductions in LTFU for patients initiating in subsequent years.

Indexed as

Lost to Follow-UpAdultAgedAnti-Retroviral AgentsAsiaFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedRisk AssessmentYoung AdultAnti-Retroviral Agents

Identifiers

PMID28129256
PMCPMC5340624
OpenAlexW2585288410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.